Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-04-014 ISMRM Abstract

Clinical optimisation of AI-based MELD-GRAPH classifier to localise epileptogenic foci in pediatric focal cortical dysplasia

Primary: Pediatrics - Neuro
Secondary: Neuro - Epilepsy
562-04-014 · AI/DL in Pediatrics · Wednesday, 13 May, 2:35 PM–3:30 PM · Digital Posters Row C
Keywords: MRI MP2RAGE Paediatric epilepsy Neural Network Focal Cortical Dysplasia
Accepted
Enrico De Vita1,2, Annemarie Knill1, Mathilde Ripart3, Kiran Seunarine2, Yi Jie Li 4, Suresh Pujar5, J Helen Cross6, M Zubair Tahir7, Friederike Moeller8, Konrad Wagstyl4,9, Sophie Adler4, Sniya Sudhakar10, Pritika Gaur10, Kshitij Mankad10, Asthik Biswas10, Ulrike Loebel10, aswin chari7, Martin Tisdall7, Felice D'Arco10,11
1MR Physics Group. Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
2Developmental Imaging and Biophysics Unit. Department of Developmental Neuroscience, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
3School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom
4UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom
5Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
6UCL Great Ormond Street Institute of Child Health, London, United Kingdom
7Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
8Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
9Department of Biomedical Computing and Early Life Imaging, King's College London, London, United Kingdom
10Neuroradiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
11Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
Presenting Author: Yi Jie Li

Synopsis

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References

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7. Spitzer H, ..., Wagstyl K. Interpretable surface-based detection of focal cortical dysplasias: a Multi-centre Epilepsy Lesion Detection study. Brain. 2022 Nov 21;145(11):3859-3871. doi: 10.1093/brain/awac224. PMID: 35953082; PMCID: PMC9679165. [doi] [pmid]
8. Ripart M, ..., Wagstyl K; MELD FCD writing group. Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study. JAMA Neurol. 2025 Feb 24;82(4):397–406. doi: 10.1001/jamaneurol.2024.5406. Epub ahead of print. Erratum in: JAMA Neurol. 2025 Apr 1;82(4):423. doi: 10.1001/jamaneurol.2025.0947. PMID: 39992650; PMCID: PMC11851297. [doi] [pmid]
9. Middlebrooks EH, Lin C, Westerhold E, Okromelidze L, Vibhute P, Grewal SS, Gupta V. Improved detection of focal cortical dysplasia using a novel 3D imaging sequence: Edge-Enhancing Gradient Echo (3D-EDGE) MRI. Neuroimage Clin. 2020;28:102449. doi: 10.1016/j.nicl.2020.102449. Epub 2020 Sep 28. PMID: 33032066; PMCID: PMC7552096. [doi] [pmid]
10. Warren AEL, Dalic LJ, Thevathasan W, Roten A, Bulluss KJ, Archer J. Targeting the centromedian thalamic nucleus for deep brain stimulation. J Neurol Neurosurg Psychiatry. 2020 Apr;91(4):339-349. doi: 10.1136/jnnp-2019-322030. Epub 2020 Jan 24. PMID: 31980515. [doi] [pmid]
11. Pastore LV, Sudhakar SV, Mankad K, De Vita E, Biswas A, Tisdall MM, Chari A, Figini M, Tahir MZ, Adler S, Moeller F, Cross JH, Pujar S, Wagstyl K, Ripart M, Löbel U, Cirillo L, D'Arco F. Integrating standard epilepsy protocol, ASL-perfusion, MP2RAGE/EDGE and the MELD-FCD classifier in the detection of subtle epileptogenic lesions: a 3 Tesla MRI pilot study. Neuroradiology. 2025 Mar;67(3):665-675. doi: 10.1007/s00234-024-03488-8. Epub 2024 Oct 23. PMID: 39441414. [doi] [pmid]
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13. Wagstyl K, Adler S, Ripart M, personal communication following interaction with users of the Multi-centre Epilepsy Lesion Detection (MELD) project (October 2025)

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http://echo.ismrm.org/p/ISMRM2026/562-04-014