Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
566-01-001 ISMRM Abstract

Distinct Microstructural Profiles of Genetic and Multi-Factor Dementia Risk Revealed by Soma and Neurite Density Imaging

Primary: Neuro - Dementia
Secondary: Diffusion - Microstructure
566-01-001 · Detectable Changes in Dementia · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row G
Keywords: Alzheimer's Disease Microstructure SANDI model APOE4 Dementia Risk
Accepted
Robert C Davis 1, Louisa E Wood1, Marco Palombo2, Derek K Jones1, Lucy V Hiscox1
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2Cardiff University Brain Research Imaging Centre (CUBRIC), School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom
Presenting Author: Robert C Davis

Synopsis

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References

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3. Vanderlip, C.R. and C.E.L. Stark, APOE4 Increases Susceptibility to Amyloid, Accelerating Episodic Memory Decline. bioRxiv, 2024.
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12. Andersson, J.L.R. and S.N. Sotiropoulos, An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage, 2016. 125: p. 1063-1078.
13. Suryanarayana Umesh Rudrapatna, G.D.P., Jamie Roberts, and Derek K Jones., Can we correct for interactions between subject motion and gradient-nonlinearity in diffusion MRI, in International Society for Magnetic Resonance Imaging in Medicine 2018.
14. Mole, J.P., et al., APOE-ε4-related differences in left thalamic microstructure in cognitively healthy adults. Sci Rep, 2020. 10(1): p. 19787.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/566-01-001