Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
501-04-007 ISMRM Abstract

Multi-Center Conformance Testing of New Chemical Shift Encoded MRI Methods for Hepatic PDFF in Phantom and In Vivo

Primary: Body - Liver
Secondary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis
501-04-007 · Applications of Quantitative MRI in the Body · Wednesday, 13 May, 4:00 PM–5:50 PM · Hall 1A
Keywords: Precision & Accuracy Proton density fat fraction (PDFF) Quality Assurance Chemical Shift-Encoded MRI Conformance
Accepted
Julius F Heidenreich 1,2, Nikolaos Panagiotopoulos1, Daiki Tamada1, Raphael do Vale Souza1, Alexandra A Anagnostopoulos1, David T Harris1, Jake Weeks3, Lael Ceriani3, Gavin Hamilton3, Sami B Khoury3, Piper Mahn3, Jacqueline Diep3, Sophia M Koehler3, Michael C Olson4, Venkata Meduri1, Sudhakar Venkatesh5, Claude B Sirlin3, Jean H Brittain6, Diego Hernando1,7, Nancy Obuchowski8,9, Takeshi Yokoo10, Scott B Reeder1,7,11,12,13
1Department of Radiology, University of Wisconsin - Madison, Madison, United States of America
2Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany
3Department of Radiology, University California San Diego, United States of America
4Department of Radiology, Mayo Clinic Rochester, Rochester, United States of America
5Mayo Clinic Rochester, Rochester, United States of America
6Calimetrix, Madison, United States of America
7Department of Medical Physics, University of Wisconsin - Madison, Madison, United States of America
8Program of Advanced Musculoskeletal Imaging (PAMI), Cleveland Clinic, Cleveland, United States of America
9Department of Quantitative Health Science, Lerner Research Institute, Cleveland Clinic, Cleveland, United States of America
10Department of Radiology, University of Texas Southwestern Medical Center, Dallas, United States of America
11Department of Biomedical Engineering, University of Wisconsin - Madison, Madison, United States of America
12Department of Medicine, University of Wisconsin - Madison, Madison, United States of America
13Department of Emergency Medicine, University of Wisconsin - Madison, Madison, United States of America
Presenting Author: Julius F Heidenreich

Synopsis

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References

1. Reeder SB, Cruite I, Hamilton G, et al. Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging. 2011;34(4). doi:10.1002/jmri.22775 [doi]
2. Hu HH, Yokoo T, Bashir MR, et al. Linearity and bias of proton density fat fraction as a quantitative imaging biomarker: A multicenter, multiplatform, multivendor phantom study. Radiology. 2021;298(3):640-651. doi:10.1148/radiol.2021202912 [doi]
3. Yokoo T, Serai SD, Pirasteh A, et al. Linearity, Bias, and Precision of Hepatic Proton Density Fat Fraction Measurements by Using MR Imaging: A Meta-Analysis. Radiology. 2018;286(2):486-498. doi:10.1148/radiol.2017170550 [doi]
4. Obuchowski NA, Buckler A, Kinahan P, et al. Statistical Issues in Testing Conformance with the Quantitative Imaging Biomarker Alliance (QIBA) Profile Claims. Acad Radiol. 2016;23(4):496-506. doi:10.1016/j.acra.2015.12.020 [doi]
5. Siu A, Solywoda MJ, Davis T, et al. Testing the Quantitative Imaging Biomarkers Alliance (QIBA) PDFF Profile in the Liver: Results from 416 Scanners at 1.5T and 3T. In: Proc. Intl. Soc. Mag. Reson. Med. 32. ; 2024. doi:10.58530/2024/0546 [doi]
6. Zhao R, Zhang Y, Wang X, et al. Motion-robust, high-SNR liver fat quantification using a 2D sequential acquisition with a variable flip angle approach. Magn Reson Med. 2020;84(4):2004-2017. doi:10.1002/mrm.28263 [doi]
7. Starekova J, Zhao R, Colgan TJ, et al. Improved free-breathing liver fat and iron quantification using a 2D chemical shift-encoded MRI with flip angle modulation and motion-corrected averaging. Eur Radiol. 2022;32(8):5458-5467. doi:10.1007/S00330-022-08682-X [doi]
8. Tang J, Tamada D, Yong X, et al. Vendor-Neutral Development and Cross-Center Validation of Flip Angle Modulated 2D Sequential CSE-MRI Technique for Liver Fat Quantification. Proc Intl Soc Mag Reson Med. 2024;0955. doi: 10.58530/2024/0955 [doi]
9. Tang J, Tamada D, do Vale Souza R, et al. Optimization of Parallel Imaging in Flip Angle Modulated 2D Sequential CSE-MRI for SNR-Efficient and Motion-Robust Liver Fat Quantification. Proc Intl Soc Mag Reson Med. 2024;4627., doi: 10.58530/2024/4627 [doi]
10. Tang J, Tamada D, Starekova J, et al. Bipolar Readouts Improve Quantitative Performance of Motion-Robust, Flip-Angle Modulated PDFF and R2* Mapping at High R2*. Proc Intl Soc Magn Reson Med. Published online 2025, doi: 10.58530/2025/3215 [doi]
11. Tang J, Tamada D, do Vale Souza R, et al. Optimized motion-insensitive PDFF mapping of the liver. Magn Reson Med. 2025, doi:10.1002/mrm.70047 [doi]
12. Tang J, Tamada D, Fujita S, et al. Vendor-Neutral, Free-Breathing Fat Quantification Demonstrates Low Bias and High Reproducibility Across Centers at 0.55T, 1.5T, and 3T. Proc Intl Soc Magn Reson Med. Published online 2025, doi: 10.58530/2025/4594 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/501-04-007