Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
461-05-001 ISMRM Abstract

Inferring local hemodynamics with PC-fMRA measures in arteries and veins: initial results estimating artery-vein transit time

Primary: Brain Function and fMRI - Task/Intervention Based fMRI
Secondary: Neuro - Blood Vessels
461-05-001 · Advances in Neuroimaging and Biomarkers for Brain Health and Disease · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row B
Keywords: BOLD-fMRI Biophysical model
Accepted
Zhangxuan Hu1,2, Grant Hartung3, Sébastien Proulx1,2, Divya Varadarajan, Bruce Rosen4,5,6, Jonathan R Polimeni 1,2
1Richard M. Lucas Center for Imaging, Stanford University, Stanford, United States of America
2Department of Radiology, Stanford Medicine, Stanford, United States of America
3Institute for Mechanics, Computational Mechanics Group, Technical University of Darmstadt, Darmstadt, Germany
4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States of America
5Department of Radiology, Harvard Medical School, Boston, United States of America
6Harvard-MIT Program in Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, United States of America
Presenting Author: Jonathan R Polimeni

Synopsis

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References

1. Iadecola C. The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease. Neuron 2017;96:17-42.
2. Schaeffer S, Iadecola C. Revisiting the neurovascular unit. Nat Neurosci 2021;24:1198-1209.
3. Hu Z, Proulx S, Hartung GA, et al. Visual stimulus-evoked blood velocity responses in individual human posterior cerebral arteries measured with dynamic phase-contrast functional MR angiography. Imaging Neurosci (Camb) 2025;3.
4. Hu Z, Proulx S, Varadarajan D, Gomez D, Bollmann S, Polimeni JR. Progression of visual-stimulus-evoked blood velocity response timing across individual arteries and veins measured with phase-contrast fMRA.  Proc Intl Soc Mag Reson Med; 2025; Honolulu, HI. Abstract #0215.
5. Buxton RB, Wong EC, Frank LR. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 1998;39:855-864.
6. Mandeville JB, Marota JJ, Ayata C, et al. Evidence of a cerebrovascular postarteriole windkessel with delayed compliance. J Cereb Blood Flow Metab 1999;19:679-689.
7. Boynton GM, Engel SA, Glover GH, Heeger DJ. Linear systems analysis of functional magnetic resonance imaging in human V1. J Neurosci 1996;16:4207-4221.
8. Glover GH. Deconvolution of impulse response in event-related BOLD fMRI. NeuroImage 1999;9:416-429.
9. Mareyam A, Kirsch JE, Chang Y, Madan G, Lawrence W. A 64-Channel 7T array coil for accelerated brain MRI.  Proc Intl Soc Mag Reson Med; 2020; Abstract #0764.
10. Kelly ME, Blau CW, Griffin KM, Gobbo OL, Jones JF, Kerskens CM. Quantitative functional magnetic resonance imaging of brain activity using bolus-tracking arterial spin labeling. J Cereb Blood Flow Metab 2010;30:913-922.
11. Li Y, Wei W, Wang RK. Capillary flow homogenization during functional activation revealed by optical coherence tomography angiography based capillary velocimetry. Sci Rep 2018;8:4107.
12. Havlicek M, Roebroeck A, Friston K, Gardumi A, Ivanov D, Uludag K. Physiologically informed dynamic causal modeling of fMRI data. NeuroImage 2015;122:355-372.
13. Weisskoff RM, Chesler D, Boxerman JL, Rosen BR. Pitfalls in MR measurement of tissue blood flow with intravascular tracers: which mean transit time? Magn Reson Med 1993;29:553-558.
14. Zong X, Lin W. Quantitative phase contrast MRI of penetrating arteries in centrum semiovale at 7T. NeuroImage 2019;195:463-474.

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http://echo.ismrm.org/p/ISMRM2026/461-05-001