Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
503-02-004 ISMRM Abstract

Correlation of diffusion anisotropy measurements from phase-contrast micro-CT and DTI in prostate tissue

Primary: Diffusion - Simulation/Validation
Secondary: Diffusion - DWI/DTI/DKI
503-02-004 · Body Diffusion MRI · Wednesday, 13 May, 1:40 PM–3:30 PM · Auditorium 1
Keywords: Diffusion Tensor Imaging Diffusion Microstructure 16.4T Microscopic CT Prostate tissue
Accepted
Adam Phipps 1, Geoffrey Watson2, Paul Sved3, Benedicta Arhatari4, Nyoman D Kurniawan5, Roger Bourne6,7
1Centre for Medical Imaging, Division of Medicine, University College London, London, United Kingdom
2New South Wales Health Pathology, Sydney, Australia
3School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
4ANSTO Australian Synchrotron, Australia
5Australian Institute for Bioengineering and Nanotechnology, Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia
6The University of Sydney, Sydney, Australia
7Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia
Presenting Author: Adam Phipps

Synopsis

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References

1. Alyami W, Kyme A, Bourne R. Histological Validation of MRI: A Review of Challenges in Registration of Imaging and Whole-Mount Histopathology. Journal of Magnetic Resonance Imaging. 2022;55(1):11-22. doi:10.1002/jmri.27409 [doi]
2. Walsh CL, Tafforeau P, Wagner WL, et al. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography. Nat Methods. 2021;18(12):1532-1541. doi:10.1038/s41592-021-01317-x [doi]
3. Momose A, Takeda T, Itai Y, Hirano K. Phase–contrast X–ray computed tomography for observing biological soft tissues. Nat Med. 1996;2(4):473-475. doi:10.1038/nm0496-473 [doi]
4. Trinkle S, Foxley S, Kasthuri N, La Rivière P. Synchrotron X-ray micro-CT as a validation dataset for diffusion MRI in whole mouse brain. Magn Reson Med. 2021;86(2):1067-1076. doi:https://doi.org/10.1002/mrm.28776 [doi]
5. Bourne RM, Kurniawan N, Cowin G, Sved P, Watson G. Microscopic diffusion anisotropy in formalin fixed prostate tissue: Preliminary findings. Magn Reson Med. 2012;68(6):1943-1948. doi:10.1002/mrm.24179 [doi]
6. Brunet J, Walsh CL, Wagner WL, et al. Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility. Nat Protoc. 2023;18(5):1441-1461. doi:10.1038/s41596-023-00804-z [doi]
7. Khan AR, Cornea A, Leigland LA, Kohama SG, Jespersen SN, Kroenke CD. 3D structure tensor analysis of light microscopy data for validating diffusion MRI. Neuroimage. 2015;111:192-203. doi:https://doi.org/10.1016/j.neuroimage.2015.01.061 [doi]
8. Panagiotaki E, Hall MG, Siow B, Lythgoe MF, Alexander DC. Three-dimensional models of tissue microstructure for simulating high-precision diffusion MRI data. In: Proc. Intl. Soc. Mag. Reson. Med. Vol 18. ; 2010:1578.

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http://echo.ismrm.org/p/ISMRM2026/503-02-004