Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-03-005 ISMRM Abstract

Low frequency fourth ventricle cerebrospinal fluid inflow and vascular reactivity in Cerebral Amyloid Angiopathy

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Neurofluids
665-03-005 · fMRI: Applications in Neurology and Psychiatry III · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row F
Keywords: fMRI Analysis Stroke Task/Intervention Based fMRI Cerebrovascular disease Cerebrospinal fluid (CSF) dynamics
Accepted
Thijs W van Harten 1, Hilde van den Brink2, Leon P Munting3, Laura D Lewis4,5,6,7,8,9,10,11, Steven M Greenberg2, Mahmut E Gurol2, Susanne J van Veluw2,12
1Massachusetts General Hospital, Boston, United States of America
2Department of Neurology, Massachusetts General Hospital, Boston, United States of America
3C.J. Gorter MRI Center, Department of Radiology, LUMC, Leiden, Netherlands
4Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
5Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
6Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, United States of America
7Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, United States of America
8Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, United States of America
9Department of Radiology, Harvard Medical School, Boston, United States of America
10Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
11Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, United States of America
12BHF-UK DRI Centre for Vascular Dementia Research, University of Edinburgh, Edinburgh, United Kingdom
Presenting Author: Thijs W van Harten

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References

1. van Veluw SJ, Benveniste H, Bakker ENTP, Carare RO, Greenberg SM, Iliff JJ, Lorthois S, Van Nostrand WE, Petzold GC, Shih AY, van Osch MJP. Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies. Cell Mol Life Sci. 2024 May 27;81(1):239. doi: 10.1007/s00018-024-05277-1. PMID: 38801464; PMCID: PMC11130115. [doi] [pmid]
2. Dumas A, Dierksen GA, Gurol ME, Halpin A, Martinez-Ramirez S, Schwab K, Rosand J, Viswanathan A, Salat DH, Polimeni JR, Greenberg SM. Functional magnetic resonance imaging detection of vascular reactivity in cerebral amyloid angiopathy. Ann Neurol. 2012 Jul;72(1):76-81. doi: 10.1002/ana.23566. PMID: 22829269; PMCID: PMC3408630. [doi] [pmid]
3. Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, Lewis LD. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019 Nov 1;366(6465):628-631. doi: 10.1126/science.aax5440. PMID: 31672896; PMCID: PMC7309589. [doi] [pmid]
4. Williams SD, Setzer B, Fultz NE, Valdiviezo Z, Tacugue N, Diamandis Z, Lewis LD. Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. PLoS Biol. 2023 Mar 30;21(3):e3002035. doi: 10.1371/journal.pbio.3002035. Erratum in: PLoS Biol. 2023 Apr 26;21(4):e3002123. doi: 10.1371/journal.pbio.3002123. PMID: 36996009; PMCID: PMC10062585. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/665-03-005