Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
302-02-010 ISMRM Abstract

Simplifying Hyperpolarized Xenon Pulmonary Gas-Exchange MRI

Primary: Body - Lung
Secondary: Contrast Mechanisms - Hyperpolarized MR (Gas)
302-02-010 · Take a Breath: Chest, Thoracic, and Pulmonary MRI · Monday, 11 May, 8:20 AM–10:10 AM · Hall 1B
Keywords: Hyperpolarized Xenon-129 MRI Dissolved-phase imaging Gas Exchange Dixon Decomposition
Accepted
Seth N Lee 1, Suphachart Leewiwatwong2, Anna Costelle1, David Mummy1,3,4, Bastiaan Driehuys1,2,4, John P Mugler5
1Medical Physics Graduate Program, Duke University, Durham, United States of America
2Department of Biomedical Engineering, Duke University, Durham, United States of America
3Duke University, Durham, United States of America
4Department of Radiology, Duke University, Durham, United States of America
5University of Virginia, Charlottesville, United States of America
Presenting Author: Seth N Lee

Synopsis

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References

1. Niedbalski PJ, Hall CS, Castro M, et al. Protocols for multi-site trials using hyperpolarized (129) Xe MRI for imaging of ventilation, alveolar-airspace size, and gas exchange: A position paper from the (129) Xe MRI clinical trials consortium. Magn Reson Med 2021;86(6):2966–2986 doi:10.1002/mrm.28985. [doi]
2. Willmering M, Matheson A, Niedbalski P, Cleveland Z, Walkup L, Woods J. Assessment of Sequence and Assumption Imperfections on 1-point Dixon 129Xe Gas Exchange MRI Metrics. 2025 ISMRM & ISMRT Annual Meeting & Exhibition. Honolulu, HI; 2025.
3. Ma J. A single-point Dixon technique for fat-suppressed fast 3D gradient-echo imaging with a flexible echo time. J Magn Reson Imaging 2008;27(4):881–890 doi:10.1002/jmri.21281. [doi]
4. Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A 2006;103(48):18278–18283 doi:10.1073/pnas.0608458103. [doi]
5. Niedbalski PJ, Lu J, Hall CS, et al. Utilizing flip angle/TR equivalence to reduce breath hold duration in hyperpolarized (129) Xe 1-point Dixon gas exchange imaging. Magn Reson Med 2022;87(3):1490–1499 doi:10.1002/mrm.29040. [doi]
6. Leewiwatwong S, Bechtel A, Mummy D, et al. Establishing standardized healthy reference distributions and values for multisite (129)Xe gas exchange MRI/MR spectroscopy at 3 T across major scanner platforms. Magn Reson Med 2025;94(4):1684–1699 doi:10.1002/mrm.30586. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/302-02-010