430-04-004 ISMRM Abstract

Targeted 19F MRI Reveals Neutrophil-driven Inflammation in Takotsubo Syndrome

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods

Secondary: Cardiovascular - Inflammation, Infiltration

430-04-004 · Cardiovascular and Body Imaging · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 2.60

Keywords: Cell Tracking & Reporter Genes Inflammation Myocardium 19F MRI Cardiovascular magnetic resonance

Accepted

Ulrich Flögel ¹, Katharina Kurz², Pascal Bouvain¹, Patricia Kleimann¹, Elias Rawish², Thomas Stiermaier²

¹Institute for Molecular Cardiology, Experimental Cardiovascular Imaging, Heinrich Heine University, Düsseldorf, Germany

²University Hospital Schleswig-Holstein, Medical Clinic II, Lübeck, Germany

Presenting Author: Ulrich Flögel

Synopsis

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References

1. Shao Y, Redfors B, Ståhlman M, Täng MS, Miljanovic A, Möllmann H, et al. A mouse model reveals an important role for catecholamine-induced lipotoxicity in the pathogenesis of stress-induced cardiomyopathy. Eur J Heart Fail. 2013 Jan;15(1):9–22. doi:10.1093/eurjhf/hfs161 [doi]

2. Liao X, Chang E, Tang X, Watanabe I, Zhang R, Jeong HW, et al. Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy. JCI Insight. 2022 Feb 8;7(3):e156236. doi:10.1172/jci.insight.156236 [doi]

3. Bouvain P, Ding Z, Kadir S, Kleimann P, Kluge N, Tiren ZB, et al. Non-invasive mapping of systemic neutrophil dynamics upon cardiovascular injury. Nat Cardiovasc Res. 2023 Feb;2(2):126–43. doi:10.1038/s44161-022-00210-w [doi]

4. Flögel U, Temme S, Jacoby C, Oerther T, Keul P, Flocke V, et al. Multi-targeted 1H/19F MRI unmasks specific danger patterns for emerging cardiovascular disorders. Nat Commun. 2021 Oct 6;12(1):5847. doi:10.1038/s41467-021-26146-6 [doi]

5. Haberkorn SM, Jacoby C, Ding Z, Keul P, Bönner F, Polzin A, et al. Cardiovascular magnetic resonance relaxometry predicts regional functional outcome after experimental myocardial infarction. Circ Cardiovasc Imaging. 2017 Aug 1;10(8):e006025. doi:10.1161/CIRCIMAGING.116.006025 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/430-04-004