Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
403-01-004 / 271-01-064 ISMRM Abstract

Combined MR – histology – micron-resolution fiber mapping towards multimodal microscopic validation of MRI

Primary: Diffusion - Tractography
Secondary: Neuro - White Matter
403-01-004 · Diffusion Tractography · Tuesday, 12 May, 8:20 AM–10:10 AM · Auditorium 1
271-01-064 · ISMRM AMPC Selected Posters · Sunday, 10 May, 7:00 AM–2:00 PM · Traditional Posters
Keywords: Fiber orientation Histology-MRI registration Multimodal Validation Scattered light imaging
Accepted
Andy Liu 1, Yixin Wang2, Matthew Choi3, Derek Days4, Michael Zeineh5, Marios Georgiadis3,5
1Department of Radiology, Stanford Medicine, Stanford, United States of America
2Department of Bioengineering, Stanford University, Stanford, United States of America
3Stanford Medicine, Stanford, United States of America
4Stanford University, Stanford, United States of America
5Department of Radiology, Stanford University, Stanford, United States of America
Presenting Author: Andy Liu

Synopsis

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References

1. 1.      Axer, M. & Amunts, K. Scale matters: The nested human connectome. Science 378, 500–504 (2022).
2. 2. Sporns, O., Tononi, G. & Kötter, R. The human connectome: a structural description of the human brain. PLoS Comput. Biol. 1, e42 (2005).
3. 3. Yendiki, A. et al. Post mortem mapping of connectional anatomy for the validation of diffusion MRI. NeuroImage 256, 119146 (2022).
4. 4. Jeurissen, B., Descoteaux, M., Mori, S. & Leemans, A. Diffusion MRI fiber tractography of the brain. NMR Biomed. 32, e3785 (2019).
5. 5. Georgiadis, M. et al. Micron-resolution fiber mapping in histology independent of sample preparation. Nat. Commun. https://doi.org/10.1038/s41467-025-64896-9 (2025) doi:10.1038/s41467-025-64896-9. [doi]
6. 6. Wang, Y. et al. Precise MRI-histology coregistration of paraffin-embedded tissue with blockface imaging. Imaging Neurosci. Camb. Mass 3, IMAG.a.106 (2025).
7. 7. Huszar, I. N. et al. Tensor image registration library: Deformable registration of stand‐alone histology images to whole‐brain post‐mortem MRI data. NeuroImage 265, 119792–119792 (2023).
8. 8. Xu, C. S. et al. An open-access volume electron microscopy atlas of whole cells and tissues. Nature 599, 147–151 (2021).
9. 9. Axer, M. et al. High-resolution fiber tract reconstruction in the human brain by means of three-dimensional polarized light imaging. Front. Neuroinformatics 5, 34 (2011).
10. 10. Georgiadis, M. et al. Nanostructure-specific X-ray tomography reveals myelin levels, integrity and axon orientations in mouse and human nervous tissue. Nat. Commun. 12, (2021).
11. 11. Hyman, B. T., Van Hoesen, G. W., Kromer, L. J. & Damasio, A. R. Perforant pathway changes and the memory impairment of Alzheimer’s disease. Ann. Neurol. 20, 472–481 (1986).

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http://echo.ismrm.org/p/ISMRM2026/403-01-004