352-03-013 / 352-03-013 ISMRM Abstract

Brain-wide subarachnoid CSF circulation patterns mapped using slow-flow-sensitized phase-contrast imaging (SOPHI)

Primary: Neuro - Neurofluids

Secondary: Acquisition & Reconstruction - Pulse Sequence Design: Neuro

352-03-013 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2

Keywords: Acquisition Methods Brain Glymphatics Cerebrospinal fluid Cerebrospinal fluid flow

Accepted

Fuyixue Wang^1,2, Timothy G Reese^1,2, Lawrence L Wald^1,2, Bruce Rosen^1,2, Laura Lewis^1,3, Zijing Dong ^1,2

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America

²Department of Radiology, Harvard Medical School, Boston, United States of America

³Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, United States of America

Presenting Author: Zijing Dong

Synopsis

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References

1. Brinker T, Stopa E, Morrison J, Klinge P. A new look at cerebrospinal fluid circulation. Fluids Barriers of the CNS 2014;11:1-16.

2. Proulx ST. Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics. Cell Mol Life Sci 2021;78:2429-2457.

3. Brunori A, Vagnozzi R, Giuffrè R. Antonio Pacchioni (1665–1726): early studies of the dura mater. Journal of Neurosurgery 1993;78:515-518.

4. Iliff JJ, Wang M, Liao Y, et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Science translational medicine 2012;4:147ra111-147ra111.

5. Dong Z, Wang F, Strom AK, et al. 4D whole-brain CSF flowmetry: slow flow dynamics in ventricles and subarachnoid space. ISMRM Workshop on Neurofluids, 2022; 2022; Italy, Rome.

6. Wang F, Reese TG, Rosen BR, et al. Neural activity induces repeatable subarachnoid CSF flow responses with coherent spatial pathways: a concurrent 4D CSF flow and BOLD fMRI study. In Proceedings of the Annual Meeting of ISMRM 2025; 2025; Honolulu, USA: 0026.

7. Dong Z, Wang F, Strom AK, et al. 4D CSF flowmetry to map brain-wide slow CSF flow dynamics and patterns in subarachnoid space. Proc Intl Soc Mag Reson Med; 2023.

8. Dong Z, Wang F, Strom AK, et al. Quantifying brain-wide cerebrospinal fluid flow dynamics using slow-flow-sensitized phase-contrast MRI. bioRxiv 2025:2025.2003. 2022.644745.

9. Dong Z, Wald LL, Polimeni JR, Wang F. Single-shot echo planar time-resolved imaging for multi-echo functional MRI and distortion-free diffusion imaging. Magnetic resonance in medicine 2025;93:993-1013.

10. Wang F, Dong Z, Reese TG, et al. Echo planar time-resolved imaging (EPTI). Magnetic resonance in medicine 2019;81:3599-3615.

11. Wang F, Reese TG, Rosen BR, et al. Simultaneous 4D CSF flowmetry and BOLD fMRI using EPTI for investigation of neural activity evoked CSF flow responses. In Proceedings of Annual Meeting of ISMRM 2024; 2024; Singapore: 1188.

12. Avants BB, Tustison N, Song G. Advanced normalization tools (ANTS). Insight j 2009;2:1-35.

13. Bianciardi M, Toschi N, Edlow BL, et al. Toward an in vivo neuroimaging template of human brainstem nuclei of the ascending arousal, autonomic, and motor systems. Brain connectivity 2015;5:597-607.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-013