Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
331-01-007 / 331-01-007 ISMRM Abstract

Mapping cerebrovascular reactivity in awake mice: insights into contrast mechanisms of SORDINO ZTE sequence

Primary: Preclinical Animal & in vitro MR - Biology, Models, Methods
Secondary: Contrast Mechanisms - Perfusion
331-01-007 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
331-01-007 · Neuro Imaging and Metabolism · Monday, 11 May, 8:20 AM–10:10 AM · Roof Terrace
Keywords: Cerebrovascular reactivity FMRI contrasts BOLD-fMRI Zero TE fMRI Hypercapnia
Accepted
Hyun Seok Moon1, Geun Ho Im2, Sung-Ho Lee3,4,5, Yen-Yu Ian Shih4,5,6, Seong-Gi Kim2,7,8
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
2Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Korea, Republic of
3Center for Animal MRI, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
4Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
5Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
6University of North Carolina at Chapel Hill, Chapel Hill, United States of America
7Institute for Basic Science, Suwon, Korea, Republic of
8Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Korea, Republic of
Presenting Author: David Hike

Synopsis

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References

1. Liu, P., B. Jill, and H. Lu, Cerebrovascular reactivity (CVR) MRI with CO2 challenge: a technical review. Neuroimage, 2019. 187: p. 104-115. https://doi.org/10.1016/j.neuroimage.2018.03.047 [doi]
2. MacKinnon, M.J., et al., SORDINO for Silent, Sensitive, Specific, and Artifact-Resisting fMRI in awake behaving mice. bioRxiv, 2025. https://doi.org/10.1101/2025.03.10.642406 [doi]
3. Choi, S.-H., et al., Baseline CBV-normalized BOLD fMRI of visual stimulation in awake vs. anesthetized mice. Journal of Cerebral Blood Flow & Metabolism, 2025: p. 0271678X251351564. https://doi.org/10.1177/0271678X251351564 [doi]
4. Le, T.T., et al., Mapping cerebral perfusion in mice under various anesthesia levels using highly sensitive BOLD MRI with transient hypoxia. Science Advances, 2024. 10(9): p. eadm7605. https://doi.org/10.1126/sciadv.adm7605 [doi]
5. Leithner, C., et al., Determination of the brain–blood partition coefficient for water in mice using MRI. Journal of Cerebral Blood Flow & Metabolism, 2010. 30(11): p. 1821-1824. https://doi.org/10.1038/jcbfm.2010.160 [doi]
6. Lehto, L.J., et al., MB-SWIFT functional MRI during deep brain stimulation in rats. Neuroimage, 2017. 159: p. 443-448. https://doi.org/10.1016/j.neuroimage.2017.08.012 [doi]
7. Silva, A.C. and S.G. Kim, Pseudo‐continuous arterial spin labeling technique for measuring CBF dynamics with high temporal resolution. Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine, 1999. 42(3): p. 425-429. https://doi.org/10.1002/(SICI)1522-2594(199909)42:3<425::AID-MRM3>3.0.CO;2-S [doi]

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http://echo.ismrm.org/p/ISMRM2026/331-01-007