666-01-001 ISMRM Abstract

Demonstration of the novel hyperpolarizer technique to monitor in vivo metabolism using cross and direct polarization

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)

Secondary: Contrast Mechanisms - Novel Contrast Mechanisms

666-01-001 · Hyperpolarization: Novel Methods · Thursday, 14 May, 8:30 AM–9:25 AM · Digital Posters Row G

Keywords: Challenges Contrast Mechanisms Metabolism Preclinical Hyperpolarized 13C MRI

Accepted

Donghyun Hong ¹, Dmitry Eshchenko², Meetu Wadhwa¹, Pinelopi Moutzouri², Paola Porcari¹, agnes glemot², Alia Hassan², Marco Sacher², Marc Rossire², Marc Schnell², Stefan Zollinger², Denis Lohner³, Joerg Hinderer², Valentin Krebs², Benjamin Beyeler², Alec Beaton⁴, Roberto Melzi², Kristin Granlund⁴, Dan Vigneron^1,5, James Kempf⁴, Renuka Sriram¹

¹Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America

²Bruker Biospin, Fällanden, Switzerland

³Bruker BioSpin, Ettlingen, Germany

⁴Bruker Biospin, Billerica, United States of America

⁵Department of Neurological Surgery, University Of California, San Francisco (UCSF), United States of America

Presenting Author: Donghyun Hong

Synopsis

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References

1. Jannin, S., Bornet, A., Colombo, S. & Bodenhausen, G. Low-temperature cross polarization in view of enhancing dissolution Dynamic Nuclear Polarization in NMR. Chemical Physics Letters 517, 234–236 (2011).

2. Jannin, S., Bornet, A., Melzi, R. & Bodenhausen, G. High field dynamic nuclear polarization at 6.7 T: Carbon-13 polarization above 70% within 20 min. Chemical Physics Letters 549, 99–102 (2012).

3. Sriram, R. et al. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2- 13 C]Pyruvate. ACS Infect. Dis. 4, 797–805 (2018).

4. un, J. et al. Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models. Metabolites 11, 139 (2021).

5. Agudelo, J. P. et al. Multiparametric Magnetic Resonance Imaging and Metabolic Characterization of Patient-Derived Xenograft Models of Clear Cell Renal Cell Carcinoma. Metabolites 12, 1117 (2022).

6. Sriram, R. et al. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers 10, 313 (2018).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-01-001