Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
431-02-013 / 431-02-013 ISMRM Abstract

Imaging the interplay between hypoxia & fibrosis during gynecologic cancer radiotherapy using R2* & LGE-IR-UTE MRI

Primary: Body - Uterus
Secondary: Contrast Mechanisms - Oxygenation
431-02-013 · A Clearer View Within: Advances in Body Imaging · Tuesday, 12 May, 1:40 PM–3:16 PM · Roof Terrace
431-02-013 · A Clearer View Within: Advances in Body Imaging · Tuesday, 12 May, 1:40 PM–3:16 PM · Roof Terrace
Accepted
Khadija Sheikh1, Bruce L Daniel2, Junghoon Lee1, Himanshu Bhat3, Pan Su3, Ravi T Seethamraju 3, Akila N Viswanathan1, Ehud J Schmidt1,4
1Radiation Oncology and Molecular Imaging, Johns Hopkins University, Baltimore, United States of America
2Department of Radiology, Stanford University, Stanford, United States of America
3Siemens Medical Solutions, Boston, United States of America
4Medicine (Cardiology), Johns Hopkins University, Baltimore, United States of America
Presenting Author: Ravi T Seethamraju

Synopsis

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References

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2. Sheikh, K. et al. Monitoring early response to low-dose Radiation Therapy with UTE Diffuse and Dense fibrosis imaging in swine and cervical cancer patients. in International Society for Magnetic Resonance in Medicine (Honolulu, 2025).
3. Iles, L. et al. Evaluation of Diffuse Myocardial Fibrosis in Heart Failure With Cardiac Magnetic Resonance Contrast-Enhanced T1 Mapping. J Am Coll Cardiol 52, 1574–1580 (2008).
4. Ricco, A. et al. Cardiac MRI utilizing late gadolinium enhancement (LGE) and T1 mapping in the detection of radiation induced heart disease. Cardio-Oncology 6, 1–9 (2020).
5. Jackson, E. F. et al. Magnetic Resonance Imaging of Therapy-Induced Necrosis Using Gadolinium-Chelated Polyglutamic Acids. Int J Radiat Oncol Biol Phys 68, 830–838 (2007).
6. Pop, M. et al. Quantification of fibrosis in infarcted swine hearts by ex vivo late gadolinium-enhancement and diffusion-weighted MRI methods. Phys Med Biol 58, 5009–5028 (2013).
7. Sheikh, K. et al. Inversion-recovery ultrashort-echo-time (IR-UTE) MRI-based detection of radiation dose heterogeneity in gynecologic cancer patients treated with HDR brachytherapy. Radiation Oncology 19, (2024).
8. Hallac, R. R. et al. Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T. NMR Biomed 25, 1321–1330 (2012).
9. Mahajan, A. et al. Role of 3T multiparametric-MRI with BOLD hypoxia imaging for diagnosis and post therapy response evaluation of postoperative recurrent cervical cancers. Eur J Radiol Open 3, 22–30 (2016).
10. Spees, W. M., Yablonskiy, D. A., Oswood, M. C. & Ackerman, J. J. H. Water proton MR properties of human blood at 1.5 Tesla: Magnetic susceptibility, T1, T2*, T2, and non-Lorentzian signal behavior. Magn Reson Med 45, 533–542 (2001).
11. Lin, E. Collagen quantification across human skeletal muscles. (University of California San Diego, San Diego, 2011).
12. Binder-Markey, B. I., Broda, N. M. & Lieber, R. L. Intramuscular Anatomy Drives Collagen Content Variation Within and Between Muscles. Front Physiol 11, (2020).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/431-02-013