Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-01-008 ISMRM Abstract

Mapping Abnormal Cerebral Hemodynamics in Patients with Sickle Cell Disease Using an Innovative BOLD fMRI Approach

Primary: Contrast Mechanisms - Oxygenation
Secondary: Brain Function and fMRI - fMRI Analysis
469-01-008 · MRI in Africa: Advancing Neuroimaging Research, Capacity, and Equity in African Populations · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row J
Keywords: Hematologic Sickle Cell Disease Cerebrovascular shunting
Accepted
Jessica J Budde1, Brianna Kish1, Ying Wang2,3, Yunjie Tong 1
1Weldon School of Biomedical Engineering, Purdue University, West Lafayette, United States of America
2Department of Anesthesia, Indiana University School of Medicine, Indianapolis, United States of America
3Division of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, United States of America
Presenting Author: Yunjie Tong

Synopsis

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References

1. Rees DC, Williams TN, Gladwin MT. Sickle-cell disease. The Lancet. 2010;376:2018–49. doi: 10.1016/S0140-6736(10)61029-X [doi]
2. DeBaun MR, Derdeyn CP, McKinstry RC. Etiology of strokes in children with sickle cell anemia. Vol. 12, Mental Retardation and Developmental Disabilities Research Reviews. 2006. doi: 10.1002/mrdd.20118 [doi]
3. Hirtz D, Kirkham FJ. Sickle Cell Disease and Stroke. Vol. 95, Pediatric Neurology. 2019. doi: 10.1016/j.pediatrneurol.2019.02.018 [doi]
4. Jordan LC, DeBaun MR, Donahue MJ. Advances in neuroimaging to improve care in sickle cell disease. Vol. 20, The Lancet Neurology. 2021. doi: 10.1016/S1474-4422(20)30490-7 [doi]
5. Juttukonda MR, Donahue MJ, Davis LT, Gindville MC, Lee CA, Patel NJ, et al. Preliminary evidence for cerebral capillary shunting in adults with sickle cell anemia. Journal of Cerebral Blood Flow and Metabolism. 2019 Jun 1;39(6):1099–110. doi: 10.1177/0271678X17746808 [doi]
6. Eldeniz C, Binkley MM, Fields M, Guilliams K, Ragan DK, Chen Y, et al. Bulk volume susceptibility difference between deoxyhemoglobin and oxyhemoglobin for HbA and HbS: A comparative study. Magn Reson Med. 2021 Jun 1;85(6):3383–93. https://doi.org/10.1002/mrm.28668 [doi]
7. Kish B, Yao J (Fiona), Frels AJ, Budde J, Nair VV, Pucka AQ, et al. Novel identifications of cerebral hemodynamics using BOLD fMRI in patients with sickle cell disease. Imaging Neuroscience. 2025 May 2. https://doi.org/10.1162/IMAG.a.1 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/469-01-008