Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
663-04-008 ISMRM Abstract

Myelin-driven structural network redundancy underlies cognitive function in cerebral small vessel disease

Primary: Neuro
Secondary: Diffusion
663-04-008 · Cerebral Small Vessel Disease: Network, Glymphatic, and Blood Flow · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row D
Keywords: Myelin Cognitive Function Normal-Appearing White Matter Cerebral Small Vessel Disease (CSVD) Structural network redundancy
Accepted
Yage Qiu 1, Wentao Hu1, Yao Wang1, Qingyang Fu1, Ying Hu1, Qun Xu2, Hongjiang Wei3, Yan Zhou1, Yawen Sun1
1Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China
2Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, China
3School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China
Presenting Author: Yage Qiu

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Wardlaw J, Smith C, Dichgans M. Small vessel disease: mechanisms and clinical implications. The Lancet Neurology. 2019;18:684-96. doi:10.1016/S1474-4422(19)30079-1 [doi]
2. Wardlaw JM, Valdés Hernández MC, Muñoz-Maniega S. What are white matter hyperintensities made of? Relevance to vascular cognitive impairment. J Am Heart Assoc. 2015;4. doi:10.1161/jaha.114.001140 [doi]
3. Salzer JL, Zalc B. Myelination. Curr Biol. 2016;26. doi:10.1016/j.cub.2016.07.074 [doi]
4. Duering M, Biessels G, Brodtmann A, Chen C, Cordonnier C, de Leeuw F, et al. Neuroimaging standards for research into small vessel disease-advances since 2013. The Lancet Neurology. 2023;22:602-18. doi:10.1016/s1474-4422(23)00131-x [doi]
5. Li Z, Feng R, Liu Q, Feng J, Lao G, Zhang M, et al. APART-QSM: An improved sub-voxel quantitative susceptibility mapping for susceptibility source separation using an iterative data fitting method. NeuroImage. 2023;274:120148. doi:10.1016/j.neuroimage.2023.120148 [doi]
6. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. NeuroImage. 2002;15:273-89. doi:10.1006/nimg.2001.0978 [doi]
7. Tononi G, Sporns O, Edelman GM. Measures of degeneracy and redundancy in biological networks. Proc Natl Acad Sci U S A. 1999;96. doi:10.1073/pnas.96.6.3257 [doi]
8. Sachdev P, Kalaria R, O'Brien J, Skoog I, Alladi S, Black SE, et al. Diagnostic criteria for vascular cognitive disorders: a VASCOG statement. Alzheimer Dis Assoc Disord. 2014;28. doi:10.1097/wad.0000000000000034 [doi]
9. Seguin C, Sporns O, Zalesky A. Brain network communication: concepts, models and applications. #N/A. 2023;24. doi:10.1038/s41583-023-00718-5 [doi]
10. Pascoal TA, Benedet AL, Ashton NJ, Kang MS, Therriault J, Chamoun M, et al. Microglial activation and tau propagate jointly across Braak stages. Nat Med. 2021;27. doi:10.1038/s41591-021-01456-w [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/663-04-008