Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
364-06-009 ISMRM Abstract

Investigating White-Matter Pathways of Cognitive Decline in Parkinson's Disease

Primary: Diffusion - Microstructure
Secondary: Neuro - Parkinson's Disease
364-06-009 · Classification in Diffusion MRI II · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row E
Keywords: Parkinson's Disease Fixel-based analysis Diffusion MRI Mild cognitive impairment White Matter Integrity
Accepted
Rishitha Praveen 1, Ivan Campbell2, Narayan Chaurasiya1, Jessica Z K. Caldwell3, Aaron Ritter4, Zoltan Mari4, Virendra Mishra1
1Department of Radiology, University of Alabama at Birmingham, Birmingham, United States of America
2Department of Neuropsychology, University of South Alabama, Mobile, United States of America
3Department of Neuropsychology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States of America
4Department of Neurology, Cleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, United States of America
Presenting Author: Rishitha Praveen

Synopsis

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References

1. [1] Kehagia, A. A., Barker, R. A., & Robbins, T. W. (2010). Cognitive impairment in Parkinson’s disease: The dual syndrome hypothesis. Neurodegenerative Diseases, 7(1–3), 149–155.
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4. [4] Jeurissen, B., Tournier, J. D., Dhollander, T., Connelly, A., & Sijbers, J. (2014). Multi-tissue constrained spherical deconvolution for improved analysis of multi-shell diffusion MRI data. NeuroImage, 103, 411–426.
5. [5] Raffelt, D. A., Smith, R. E., Ridgway, G. R., Tournier, J. D., Vaughan, D. N., Rose, S., ... & Connelly, A. (2015). Connectivity-based fixel enhancement: Whole-brain statistical analysis of diffusion MRI measures in the presence of crossing fibres. NeuroImage, 117, 40–55.
6. [6] Raffelt, D. A., Tournier, J. D., Smith, R. E., Vaughan, D. N., Jackson, G., Ridgway, G. R., & Connelly, A. (2017). Investigating white matter fibre density and morphology using fixel-based analysis. NeuroImage, 144, 58–73.
7. [7] Tournier, J. D., Smith, R., Raffelt, D., Tabbara, R., Dhollander, T., Pietsch, M., ... & Connelly, A. (2019). MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation. NeuroImage, 202, 116137.
8. [8] Veraart, J., Fieremans, E., & Novikov, D. S. (2016). Diffusion MRI noise mapping using random matrix theory. Magnetic Resonance in Medicine, 76(5), 1582–1593.
9. [9] Hall, J. M., O’Callaghan, C., Shine, J. M., Muller, A. J., Phillips, J. R., & Lewis, S. J. G. (2016). Changes in white matter integrity relate to cognitive impairment in Parkinson’s disease. NeuroImage: Clinical, 11, 418–424.
10. [10] Pereira, J. B., Aarsland, D., Ginestet, C. E., Lebedev, A. V., Wahlund, L. O., Simmons, A., & Westman, E. (2014). Aberrant cerebral network topology and mild cognitive impairment in early Parkinson’s disease. Human Brain Mapping, 36(8), 2980–2995.
11. [11] Wen, M. C., Ng, A., Tan, L. C. S., & Chan, L. L. (2016). The neuroimaging signatures of Parkinson’s disease: A focus on cognitive impairment and dementia. Journal of Neurological Sciences, 371, 194–206.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/364-06-009