2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
404-03-005 ISMRM Abstract

Multiple Inversion Recovery GRE as a novel imaging marker for myelin state and axonal damage in MS lesions

Primary: Neuro - Multiple Sclerosis
Secondary: Contrast Mechanisms - Microstructure
404-03-005 · Multiscale MRI in Neuroinflammation · Tuesday, 12 May, 1:40 PM–3:30 PM · Ballroom East
Keywords: Contrast Mechanisms Neurodegeneration Multiple Sclerosis Neuroinflammation Microstructural abnormalities
Accepted
Dimitrios G Gkotsoulias 1,2, Lukas Schönenberger1,2, Jochen Leupold3, Ilaria Callegari1,2, Matthias Weigel1,2, Erik Bahn4, Christine Stadelmann4, Valerij G Kiselev3,5, Dominik von Elverfeldt3, Ludwig Kappos1,2, Cristina Granziera1,2
1Department of Neurology, University Hospital Basel, Basel, Switzerland
2University Hospital Basel, Basel, Switzerland
3University Medical Center Freiburg, Freiburg, Germany
4Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany
5Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Presenting Author: Dimitrios G Gkotsoulias

Synopsis

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References

1. Jakimovski D et al. (2024) Multiple sclerosis, The Lancet, Volume 403, Issue 10422, 183 – 202
2. Granziera C, et al. Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis. Brain. 2021 Jun 22;144(5):1296-1311. doi: 10.1093/brain/awab029. [doi]
3. Galbusera, R., et al. (2023). Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis. Brain Pathology, 33(6), e13136. https://doi.org/10.1111/bpa.13136 [doi]
4. Möller HE, et al. (2019) Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology. Trends Neurosci. 2019 Jun;42(6):384-401. doi: 10.1016/j.tins.2019.03.009 [doi]
5. Bushberg JT, et al. The Essential Physics of Medical Imaging. Third edition (2012). Lippincott, Williams & Wilkins. ISBN: 9781451153941
6. Gkotsoulias D.G., Schönenberger L, et al., (2025) Bridging mesoscopic and macroscopic scales in Multiple Sclerosis: Postmortem brain block multi-contrast 9.4T MRI and histology quantification protocol, STAR Protocols-Cell Press
7. Birkl, C., et al. (2016). Effects of formalin fixation and temperature on MR relaxation times in the human brain. NMR in Biomedicine, 29(4), 458–465. https://doi.org/10.1002/nbm.3477 [doi]
8. Shepherd, T. M., et al. (2009). Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue. Magnetic Resonance in Medicine, 62(1), 26–34. https://doi.org/10.1002/mrm.21977 [doi]
9. Dusek, P., et al. (2019). The choice of embedding media affects image quality, tissue R2*, and susceptibility behaviors in post mortem brain MR microscopy at 7.0 T. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.27595 [doi]
10. Gkotsoulias, D. G., et al. (2023). High angular resolution susceptibility imaging and estimation of fiber orientation distribution functions in primate brain. NeuroImage, 276, 120202. https://doi.org/10.1016/j.neuroimage.2023.120202 [doi]
11. Birkl, C., et al. (2014). Temperature induced changes of magnetic resonance relaxation times in the human brain: A postmortem study. Magnetic Resonance in Medicine, 71(4), 1575–1580. https://doi.org/10.1002/mrm.24799 [doi]

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http://echo.ismrm.org/p/ISMRM2026/404-03-005