Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
404-03-005 ISMRM Abstract

Multiple Inversion Recovery GRE as a novel imaging marker for myelin state and axonal damage in MS lesions

Primary: Neuro - Multiple Sclerosis
Secondary: Contrast Mechanisms - Microstructure
404-03-005 · Multiscale MRI in Neuroinflammation · Tuesday, 12 May, 1:40 PM–3:30 PM · Ballroom East
Keywords: Contrast Mechanisms Neurodegeneration Multiple Sclerosis Neuroinflammation Microstructural abnormalities
Accepted
Dimitrios G Gkotsoulias 1,2,3, Lukas Schönenberger1,2,3, Jochen Leupold4, Ilaria Callegari1,2,3, Matthias Weigel1,2,3,5, Erik Bahn6, Christine Stadelmann6, Valerij G Kiselev4,7, Dominik von Elverfeldt4, Ludwig Kappos2,3, Cristina Granziera1,2,3
1Translational Imaging in Neurology (ThINk) Basel, Department of Biomedical Engineering, Faculty of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland
2Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland., Switzerland
3Research Center for Clinical Neuroimmunology and Neuroscience Basel (RC2NB), University Hospital Basel and University of Basel, Basel, Switzerland, Switzerland
4University Medical Center Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
5University Hospital Basel, Basel, Switzerland
6Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany
7Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
Presenting Author: Dimitrios G Gkotsoulias

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References

1. Jakimovski D et al. (2024) Multiple sclerosis, The Lancet, Volume 403, Issue 10422, 183 – 202
2. Granziera C, et al. Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis. Brain. 2021 Jun 22;144(5):1296-1311. doi: 10.1093/brain/awab029. [doi]
3. Galbusera, R., et al. (2023). Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis. Brain Pathology, 33(6), e13136. https://doi.org/10.1111/bpa.13136 [doi]
4. Möller HE, et al. (2019) Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology. Trends Neurosci. 2019 Jun;42(6):384-401. doi: 10.1016/j.tins.2019.03.009 [doi]
5. Bushberg JT, et al. The Essential Physics of Medical Imaging. Third edition (2012). Lippincott, Williams & Wilkins. ISBN: 9781451153941
6. Gkotsoulias D.G., Schönenberger L, et al., (2025) Bridging mesoscopic and macroscopic scales in Multiple Sclerosis: Postmortem brain block multi-contrast 9.4T MRI and histology quantification protocol, STAR Protocols-Cell Press
7. Birkl, C., et al. (2016). Effects of formalin fixation and temperature on MR relaxation times in the human brain. NMR in Biomedicine, 29(4), 458–465. https://doi.org/10.1002/nbm.3477 [doi]
8. Shepherd, T. M., et al. (2009). Aldehyde fixative solutions alter the water relaxation and diffusion properties of nervous tissue. Magnetic Resonance in Medicine, 62(1), 26–34. https://doi.org/10.1002/mrm.21977 [doi]
9. Dusek, P., et al. (2019). The choice of embedding media affects image quality, tissue R2*, and susceptibility behaviors in post mortem brain MR microscopy at 7.0 T. Magnetic Resonance in Medicine. https://doi.org/10.1002/mrm.27595 [doi]
10. Gkotsoulias, D. G., et al. (2023). High angular resolution susceptibility imaging and estimation of fiber orientation distribution functions in primate brain. NeuroImage, 276, 120202. https://doi.org/10.1016/j.neuroimage.2023.120202 [doi]
11. Birkl, C., et al. (2014). Temperature induced changes of magnetic resonance relaxation times in the human brain: A postmortem study. Magnetic Resonance in Medicine, 71(4), 1575–1580. https://doi.org/10.1002/mrm.24799 [doi]

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http://echo.ismrm.org/p/ISMRM2026/404-03-005