Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
460-06-002 ISMRM Abstract

Choroid plexus volume in Alzheimer’s disease genetic risk: an early marker of glymphatic dysfunction?

Accepted
Hannah L Chandler1, Natalie Jones1, Neil A Harrison1, Kevin Murphy 1, Thomas M Lancaster2
1Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, United Kingdom
2University of Bath, Bath, United Kingdom
Presenting Author: Kevin Murphy

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Yang, A. C., Vest, R. T., Kern, F., Lee, D. P., Agam, M., Maat, C. A., Losada, P. M., Chen, M. B., Schaum, N., Khoury, N., Toland, A., Calcuttawala, K., Shin, H., Palovics, R., Shin, A., Wang, E. Y., Luo, J., Gate, D., Schulz-Schaeffer, W. J.,…Wyss-Coray, T. (2022). A human brain vascular atlas reveals diverse mediators of Alzheimer's risk. Nature, 603(7903), 885–892. https://doi.org/10.1038/s41586-021-04369-3 [doi]
2. Faubel, R., Westendorf, C., Bodenschatz, E., & Eichele, G. (2016). Cilia-based flow network in the brain ventricles. Science, 353(6295), 176–178. https://doi.org/10.1126/science.aae0450 [doi]
3. Fischl, B. (2012). FreeSurfer. Neuroimage, 62(2), 774–781. https://doi.org/10.1016/j.neuroimage.2012.01.021 [doi]
4. Chandler, H. L., Wheeler, J., Escott-Price, V., Murphy, K., & Lancaster, T. M. (2025). Non-APOE variants predominately expressed in smooth muscle cells contribute to the influence of Alzheimer's disease genetic risk on white matter hyperintensities. Alzheimers Dement, 21(2), e14455. https://doi.org/10.1002/alz.14455 [doi]
5. Yang, H. S., Teng, L., Kang, D., Menon, V., Ge, T., Finucane, H. K., Schultz, A. P., Properzi, M., Klein, H. U., Chibnik, L. B., Schneider, J. A., Bennett, D. A., Hohman, T. J., Mayeux, R. P., Johnson, K. A., De Jager, P. L., & Sperling, R. A. (2023). Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease. medRxiv. https://doi.org/10.1101/2023.06.01.23290850 [doi]
6. Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., Amit, I., & Schwartz, M. (2014). Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science, 346(6205), 89–93. https://doi.org/10.1126/science.1252945 [doi]
7. Fleischer, V., Gonzalez-Escamilla, G., Ciolac, D., Albrecht, P., Kury, P., Gruchot, J., Dietrich, M., Hecker, C., Muntefering, T., Bock, S., Oshaghi, M., Radetz, A., Cerina, M., Kramer, J., Wachsmuth, L., Faber, C., Lassmann, H., Ruck, T., Meuth, S. G.,…Groppa, S. (2021). Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Proc Natl Acad Sci U S A, 118(36). https://doi.org/10.1073/pnas.2025000118 [doi]

Cite this abstract