Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
560-02-009 ISMRM Abstract

Biophysical contrast source of the Locus Coeruleus in ex-situ human brain at 7T: Correlation between QSM and EPR spectroscopy

Primary: Contrast Mechanisms - Susceptibility/QSM
Secondary: Analysis Methods - Data Processing
560-02-009 · New Developments in QSM II · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row A
Keywords: Brain Electron Paramagnetic Resonance Quantitative Susceptibility Mapping (QSM) Locus Coeruleus
Accepted
André Avanzine 1, Maria Garcia Otaduy2, Carlos Salmon3,4
1Department of Physics, University of Sao Paulo, Ribeirao Preto, Brazil
2University of Sao Paulo, Ribeirao Preto, Brazil
3Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil, Ribeirão Preto, Brazil
4Medical Images, Oncology and Hematology, Ribeirao Preto Medical School - University of Sao Paulo, Brazil
Presenting Author: André Avanzine

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References

1. Zecca, Luigi, et al. "The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging." Proceedings of the National Academy of Sciences 101.26 (2004): 9843-9848. https://doi.org/10.1073/pnas.0403495101 [doi]
2. Otsuka, Fábio Seiji, et al. "Biophysical contrast sources for magnetic susceptibility and R2* mapping: A combined 7 Tesla, mass spectrometry and electron paramagnetic resonance study." NeuroImage 302 (2024): 120892. https://doi.org/10.1016/j.neuroimage.2024.120892 [doi]
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4. Otsuka, Fábio Seiji, et al. "Quantification of paramagnetic ions in human brain tissue using EPR." Brazilian Journal of Physics 52.3 (2022): 94. https://doi.org/10.1007/s13538-022-01098-4 [doi]
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7. Dymerska, Barbara, et al. "Phase unwrapping with a rapid opensource minimum spanning tree algorithm (ROMEO)." Magnetic resonance in medicine 85.4 (2021): 2294-2308. https://doi.org/10.1002/mrm.28563 [doi]
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9. Sun, Hongfu, and Alan H. Wilman. "Background field removal using spherical mean value filtering and Tikhonov regularization." Magnetic resonance in medicine 71.3 (2014): 1151-1157. https://doi.org/10.1002/mrm.24765 [doi]
10. Wei, Hongjiang, et al. "Streaking artifact reduction for quantitative susceptibility mapping of sources with large dynamic range." NMR in Biomedicine 28.10 (2015): 1294-1303. https://doi.org/10.1002/nbm.3383 [doi]
11. Li, Zhenghao, et al. "APART-QSM: An improved sub-voxel quantitative susceptibility mapping for susceptibility source separation using an iterative data fitting method." Neuroimage 274 (2023): 120148. https://doi.org/10.1016/j.neuroimage.2023.120148 [doi]
12. Stoll, Stefan, and Arthur Schweiger. "EasySpin, a comprehensive software package for spectral simulation and analysis in EPR." Journal of magnetic resonance 178.1 (2006): 42-55. https://doi.org/10.1016/j.jmr.2005.08.013 [doi]

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http://echo.ismrm.org/p/ISMRM2026/560-02-009