Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
667-02-014 ISMRM Abstract

Relating microstructural properties of tendon and ligament to diffusion MRI metrics

Primary: Musculoskeletal - Tendon/Ligament
Secondary: Diffusion - Microstructure
667-02-014 · Diffusion Microstructure and Beyond · Thursday, 14 May, 9:25 AM–10:20 AM · Digital Posters Row H
Keywords: Tendon/Ligament Collagen Fractional anisotropy Collagen fiber Diffusion-weighted imaging (DWI)
Accepted
Michael Focht1, Advait Borole2, Amir O Moghaddam3, Amy J Wagoner Johnson1,4,5, Roberto A Pineda Guzman6,7, Bruce M Damon 6,8,9,10,11,12, Noel M Naughton2, Mariana E Kersh1,5,12
1Department of Mechanical Science and Engineering, University of Illinois at Urbana-Champaign, Champaign, United States of America
2Department of Mechanical Engineering, Virginia Tech, Blacksburg, United States of America
3Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, United States of America
4Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Champaign, United States of America
5Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Champaign, United States of America
6Stephens Family Clinical Research Institute, Carle Health, Urbana, United States of America
7Carle Illinois Advanced Imaging Center, Urbana, United States of America
8Department of Biomedical Engineering, Vanderbilt University, Nashville, United States of America
9Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, United States of America
10Department of Bioengineering, University of Illinois at Urbana-Champaign, Champaign, United States of America
11Department of Biomedical and Translational Sciences, University of Illinois at Urbana-Champaign, Champaign, United States of America
12Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, United States of America
Presenting Author: Bruce M Damon

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References

1. Janssen, R., Gustafsson, A., Jönsson, V., Grassi, L., Pierantoni, M., Isaksson, H., 2025. Investigating Achilles tendon adaptation to mechanical load: a computational model integrating collagen fibre orientation heterogeneity. Biomech Model Mechanobiol. https://doi.org/10.1007/s10237-025-02002-0 [doi]
2. Blank, J., Roth, J., 2024. Ligament shear strain stiffening arises from unaligned fibers and is amplified by axial strain. https://doi.org/10.31224/3587 [doi]
3. Freedman, B.R., Rodriguez, A.B., Leiphart, R.J., Newton, J.B., Ban, E., Sarver, J.J., Mauck, R.L., Shenoy, V.B., Soslowsky, L.J., 2018. Dynamic Loading and Tendon Healing Affect Multiscale Tendon Properties and ECM Stress Transmission. Sci Rep 8, 10854. https://doi.org/10.1038/s41598-018-29060-y [doi]
4. Gasser, T.C., Ogden, R.W., Holzapfel, G.A., 2006. Hyperelastic modelling of arterial layers with distributed collagen fibre orientations. J. R. Soc. Interface. 3, 15–35. https://doi.org/10.1098/rsif.2005.0073 [doi]
5. Naughton, N.M., Tennyson, C.G., Georgiadis, J.G., 2020. Lattice Boltzmann method for simulation of diffusion magnetic resonance imaging physics in multiphase tissue models. Phys. Rev. E 102, 043305. https://doi.org/10.1103/PhysRevE.102.043305 [doi]
6. Peto, S., Gillis, P., Henri, V.P., 1990. Structure and dynamics of water in tendon from NMR relaxation measurements. Biophysical Journal 57, 71–84. https://doi.org/10.1016/S0006-3495(90)82508-X [doi]
7. Henkelman, R.M., Stanisz, G.J., Kim, J.K., Bronskill, M.J., 1994. Anisotropy of NMR properties of tissues. Magnetic Resonance in Med 32, 592–601. https://doi.org/10.1002/mrm.1910320508 [doi]
8. Traore, A., Foucat, L., Renou, J.P., 2000. 1H-NMR study of water dynamics in hydrated collagen: Transverse relaxation-time and diffusion analysis. Biopolymers 53, 476–483. https://doi.org/10.1002/(sici)1097-0282(200005)53:6<476::aid-bip4>3.0.co;2-8 [doi]
9. Pierce, D.M., Trobin, W., Raya, J.G., Trattnig, S., Bischof, H., Glaser, C., Holzapfel, G.A., 2010. DT-MRI Based Computation of Collagen Fiber Deformation in Human Articular Cartilage: A Feasibility Study. Ann Biomed Eng 38, 2447–2463. https://doi.org/10.1007/s10439-010-9990-9 [doi]
10. Wright, R.M., Post, A., Hoshizaki, B., Ramesh, K.T., 2013. A Multiscale Computational Approach to Estimating Axonal Damage under Inertial Loading of the Head. Journal of Neurotrauma 30, 102–118. https://doi.org/10.1089/neu.2012.2418 [doi]
11. Giordano, C., Kleiven, S., 2014. Connecting fractional anisotropy from medical images with mechanical anisotropy of a hyperviscoelastic fibre-reinforced constitutive model for brain tissue. J. R. Soc. Interface. 11, 20130914. https://doi.org/10.1098/rsif.2013.0914 [doi]
12. Fieremans, E., De Deene, Y., Delputte, S., Özdemir, M.S., Achten, E., Lemahieu, I., 2008. The design of anisotropic diffusion phantoms for the validation of diffusion weighted magnetic resonance imaging. Phys. Med. Biol. 53, 5405–5419. https://doi.org/10.1088/0031-9155/53/19/009 [doi]
13. Guzman, R.A.P., 2023. Development of novel model materials and non-invasive microstructural imaging techniques of connective soft tissues. University of Illinois Urbana-Champaign, Urbana, IL.
14. Guzman, R.A.P., Moghaddam, A.O., Confer, M.P., Majumdar, S., Bhargava, R., Johnson, A.J.W., Damon, B.M., Kersh, M.E., n.d. Non-invasive detection of local microstructural damage in tendon via Diffusion Tensor MRI. https://doi.org/10.1101/2025.10.10.681653 [doi]

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http://echo.ismrm.org/p/ISMRM2026/667-02-014