Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
406-01-007 ISMRM Abstract

Quantitative Functional BOLD (qfBOLD) for Oxygen Extraction Fraction Mapping Using ASL-free Gradient Echo/Spin Echo fMRI

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Brain Function and fMRI - fMRI Acquisition
406-01-007 · fMRI: Acquisition and Preprocessing · Tuesday, 12 May, 8:20 AM–10:10 AM · Auditorium 2
Keywords: Oxygen extraction fraction Calibrated fMRI CMRO2 Blood Oxygen Level Dependent (BOLD) fMRI Hypercapnia
Accepted
Antonio M Chiarelli 1,2, Lucie Chalet1,2, Sara Pomante1,2, Davide Di Censo1,2, Alessandra Caporale1,2, Emma Biondetti1,2, Fabrizio Fasano3,4, DOMENICO ZACA'5,6, Giulia Rocco1,2, Manuela Carriero1,2, Francesca Graziano1,2, Elizabeth J Fear1,2, Maria Eugenia Caligiuri7,8, Richard G Wise1,2, Michael Germuska9
1Department of Neurosciences, Imaging and Clinical Sciences, University 'G.d'Annunzio' of Chieti-Pescara, Chieti, Italy
2Institute for Advanced Biomedical Technologies, University 'G.d'Annunzio' of Chieti-Pescara, Chieti, Italy
3Siemens Healthineers AG, Forchheim, Germany
4Siemens Healthcare Ltd., Camberly, United Kingdom
5Scientific Collaborations and Strategic Partnerships, Siemens Healthcare S.r.l., Milan, Italy
6Siemens Healthcare srl, Milano, Italy
7Department of Medical and Surgical Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy
8Neuroscience Research Center, University Magna Graecia of Catanzaro, Catanzaro, Italy
9Department of Radiology, University of California Davis Medical Center, Sacramento, CA, United States of America, United States of America
Presenting Author: Antonio M Chiarelli

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References

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2. Chiarelli AM, Germuska M, Chandler H, et al. A flow-diffusion model of oxygen transport for quantitative mapping of cerebral metabolic rate of oxygen (CMRO2) with single gas calibrated fMRI. J Cereb Blood Flow Metab. 2022;42(7):1192-1209. doi:10.1177/0271678X221077332 [doi]
3. He X, Zhu M, Yablonskiy DA. Validation of oxygen extraction fraction measurement by qBOLD technique. Magn Reson Med. 2008;60(4):882-888. doi:10.1002/mrm.21719 [doi]
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8. Schilling KG, Newton A, Tax CMW, et al. The relationship of white matter tract orientation to vascular geometry in the human brain. Sci Rep. 2025;15(1):18396. Published 2025 May 26. doi:10.1038/s41598-025-99724-z9 [doi]
9. Jensen JH, Chandra R. Strong field behavior of the NMR signal from magnetically heterogeneous tissues. Magn Reson Med. 2000;43(2):226-236. doi:10.1002/(sici)1522-2594(200002)43:2<226::aid-mrm9>3.0.co;2-p10. [doi]
10. Ogawa S, Menon RS, Tank DW, et al. Functional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model. Biophys J. 1993;64(3):803-812. doi:10.1016/S0006-3495(93)81441-3. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/406-01-007