565-01-013 ISMRM Abstract

Decoupling of gBOLD Signals from CSF Flow Reveals Glymphatic Dysfunction in Idiopathic Normal Pressure Hydrocephalus

Primary: Brain Function and fMRI - fMRI Analysis

Secondary: Neuro - Hydrocephalus

565-01-013 · Neuroinflammation: Fluids and Flow · Wednesday, 13 May, 8:20 AM–9:15 AM · Digital Posters Row F

Keywords: Surgery Cerebrospinal fluid flow Idiopathic normal pressure hydrocephalus Glymphatic clearance Neurovascular coupling

Accepted

思亭许 ¹

¹Department of Radiology, Huadong Hosptial, Fudan University, Shanghai, China

Presenting Author: 思亭许

Synopsis

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References

1. Fultz NE, Bonmassar G, Setsompop K, Stickgold RA, Rosen BR, Polimeni JR, Lewis LD. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019 Nov 1;366(6465):628-631. doi: 10.1126/science.aax5440 [doi]

2. Han F, Chen J, Belkin-Rosen A, Gu Y, Luo L, Buxton OM, Liu X; Alzheimer’s Disease Neuroimaging Initiative. Reduced coupling between cerebrospinal fluid flow and global brain activity is linked to Alzheimer disease-related pathology. PLoS Biol. 2021 Jun 1;19(6):e3001233. doi: 10.1371/journal.pbio.3001233 [doi]

3. Wang Z, Song Z, Zhou C, Fang Y, Gu L, Yang W, Gao T, Si X, Liu Y, Chen Y, Guan X, Guo T, Wu J, Bai X, Zhang M, Zhang B, Pu J. Reduced coupling of global brain function and cerebrospinal fluid dynamics in Parkinson's disease. J Cereb Blood Flow Metab. 2023 Aug;43(8):1328-1339. doi: 10.1177/0271678X231164337 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/565-01-013