361-06-011 ISMRM Abstract

Myelin imaging of the optic nerve

Primary: Neuro - White Matter

Secondary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI

361-06-011 · Quantitative Imaging: Head and Neck II · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row B

Keywords: Multiple Sclerosis T1 Mapping Optic nerves MP2RAGE Myelin Volume Fraction

Accepted

Hugo Albert Plante ^1,2, Ameen Qadi^3,4, Agah Karakuzu¹, Mathieu Boudreau¹, Bas Rokers^3,4, Nikola Stikov^1,3,4

¹NeuroPoly Lab, Department of Electrical Engineering, Polytechnique Montréal, Montréal, Canada

²Department of Electrical Engineering, Polytechnique Montréal, Montréal, Canada

³Center for Brain and Health, NYU Abu Dhabi, Abu Dhabi, United Arab Emirates

⁴Psychology, NYU Abu Dhabi, Abu Dhabi, United Arab Emirates

Presenting Author: Hugo Albert Plante

Synopsis

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References

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2. Toosy AT, Mason DF, Miller DH. Optic neuritis. Lancet Neurol. 2014;13(1):83-99. doi:10.1016/S1474-4422(13)70259-X [doi]

3. Smith AM, Czyz CN. Neuroanatomy, Cranial Nerve 2 (Optic). In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022. http://www.ncbi.nlm.nih.gov/books/NBK507907/. PMID: 29939684 Accessed July 25, 2025. [pmid]

4. Hickman SJ. Optic Nerve Imaging in Multiple Sclerosis. J Neuroimaging. 2007;17(s1). doi:10.1111/j.1552-6569.2007.00136.x [doi]

5. Marques JP, Kober T, Krueger G, Van Der Zwaag W, Van De Moortele PF, Gruetter R. MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. NeuroImage. 2010;49(2):1271-1281. doi:10.1016/j.neuroimage.2009.10.002 [doi]

6. Mezer A, Yeatman JD, Stikov N, et al. Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging. Nat Med. 2013;19(12):1667-1672. doi:10.1038/nm.3390 [doi]

7. Duval T, Stikov N, Cohen-Adad J. Modeling white matter microstructure. Funct Neurol. 2016. doi:10.11138/FNeur/2016.31.4.217 [doi]

8. Karakuzu A, Boudreau M, Duval T, et al. qMRLab: Quantitative MRI analysis, under one umbrella. J Open Source Softw. 2020;5(53):2343. doi:10.21105/joss.02343 [doi]

9. Sbaihat H, Roenneke K, Müller D, et al. MRI-based human brain atlases of R1, R2, proton density, and myelin volume fraction using synthetic quantitative imaging at 1.5 T. J Neurol. 2025;272(9):578. doi:10.1007/s00415-025-13317-4 [doi]

10. Fitzgibbon T, Nestorovski Z. Morphological Consequences of Myelination in the Human Retina. Exp Eye Res. 1997;65(6):809-819. doi:10.1006/exer.1997.0388 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/361-06-011