Nina Fultz 1, Madda Debiasi1, Emiel Roefs1, Geir Ringstad2,3,4, Marianne AA van Walderveen5, Jeroen de Bresser5, Matthias van Osch1, Lydiane Hirschler1
1C.J. Gorter MRI Center, Leiden University Medical Center, Netherlands
2Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway
3KG Jebsen Centre for Brain Fluid Research, Oslo, Norway
4Department of Radiology, Oslo University Hospital – Rikshospitalet, Oslo, Norway
5Department of Radiology, Leiden University Medical Center, Leiden, Netherlands
Presenting Author: Nina Fultz
Synopsis
Motivation:
Goals:
Approach:
Results:
Full abstract & presentation
The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.
Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.
To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.
1. Williams SD, Setzer B, Fultz NE, et al. Neural activity induced by sensory stimulation can drive large-scale cerebrospinal fluid flow during wakefulness in humans. PLoS Biol. 2023;21(3):e3002035. doi:10.1371/journal.pbio.3002035 [doi]
2. Smyth LCD, Xu D, Okar SV, et al. Identification of direct connections between the dura and the brain. Nature. 2024;627(8002):165-173. doi:10.1038/s41586-023-06993-7 [doi]
3. Xie L, Kang H, Xu Q, et al. Sleep Drives Metabolite Clearance from the Adult Brain. Science. 2013;342(6156):373-377. doi:10.1126/science.1241224 [doi]
4. Iliff JJ, Lee H, Yu M, et al. Brain-wide pathway for waste clearance captured by contrast-enhanced MRI. J Clin Invest. 2013;123(3):1299-1309. doi:10.1172/JCI67677 [doi]
5. Picchioni D, Özbay PS, Mandelkow H, et al. Autonomic arousals contribute to brain fluid pulsations during sleep. NeuroImage. 2022;249:118888. doi:10.1016/j.neuroimage.2022.118888 [doi]
6. Gonzalez-Castillo J, Fernandez IS, Handwerker DA, Bandettini PA. Ultra-slow fMRI fluctuations in the fourth ventricle as a marker of drowsiness. Neuroimage. 2022;259:119424. doi:10.1016/j.neuroimage.2022.119424 [doi]
7. Fultz NE, Bonmassar G, Setsompop K, et al. Coupled electrophysiological, hemodynamic, and cerebrospinal fluid oscillations in human sleep. Science. 2019;366(6465):628-631. doi:10.1126/science.aax5440 [doi]
8. Weed LH. Studies on Cerebro-Spinal Fluid. No. III. J Med Res. 1914;31(1):51-91.
9. Eide PK, Ringstad G. Functional analysis of the human perivascular subarachnoid space. Nat Commun. 2024;15(1):2001. doi:10.1038/s41467-024-46329-1 [doi]
10. Hirschler L, Runderkamp BA, Decker A, et al. Region-specific drivers of CSF mobility measured with MRI in humans. Nat Neurosci. Published online October 14, 2025:1-10. doi:10.1038/s41593-025-02073-3 [doi]
11. Møllgård K, Beinlich FRM, Kusk P, et al. A mesothelium divides the subarachnoid space into functional compartments. Science. 2023;379(6627):84-88. doi:10.1126/science.adc8810 [doi]
13. Alcolado R, Weller RO, Parrish EP, Garrod D. The Cranial Arachnoid and Pia Mater in Man: Anatomical and Ultrastructural Observations. Neuropathology and Applied Neurobiology. 1988;14(1):1-17. doi:10.1111/j.1365-2990.1988.tb00862.x [doi]
14. Zhang ET, Inman CB, Weller RO. Interrelationships of the pia mater and the perivascular (Virchow-Robin) spaces in the human cerebrum. J Anat. 1990;170:111-123.
15. Pizzo ME, Wolak DJ, Kumar NN, et al. Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery. J Physiol. 2018;596(3):445-475. doi:10.1113/JP275105 [doi]