Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
462-03-014 ISMRM Abstract

CSF flow is driven by carotid stroke volume during inspiration and IJV flow during deep breathing

Primary: Neuro - Neurofluids
Secondary: Neuro - Blood Vessels
462-03-014 · Heart and Brain Axis · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row C
Keywords: Respiratory States Cerebrospinal fluid circulation CSF Dynamics
Accepted
Brice Williams 1,2, Kunsh Sharma3, Ning Jin4, John Oshinski5,6
1Emory University School of Medicine, Atlanta, United States of America
2Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia
3Neuroscience, Georgia Institute of Technology, Atlanta, United States of America
4Magnetic Resonance Imaging, Siemens Healthineers AG, Erlangen, Germany
5Radiology & Imaging Sciences, Emory University, Atlanta, United States of America
6Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, United States of America
Presenting Author: Brice Williams

Synopsis

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References

1. Rasmussen MK, Mestre H, Nedergaard M. The glymphatic pathway in neurological disorders. Lancet Neurol. 2018;17(11):1016-24. doi: 10.1016/s1474-4422(18)30318-1. PubMed PMID: 30353860; PMCID: PMC6261373. [doi] [pmid]
2. Nedergaard M, Goldman SA. Glymphatic failure as a final common pathway to dementia. Science. 2020;370(6512):50-6. doi: 10.1126/science.abb8739. PubMed PMID: 33004510; PMCID: PMC8186542. [doi] [pmid]
3. Jansson DJ, Iliff JJ. Woes with flows under pressure. Brain Commun. 2021;3(2):fcab094. Epub 20210508. doi: 10.1093/braincomms/fcab094. PubMed PMID: 34642661; PMCID: PMC8140292. [doi] [pmid]
4. Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology. 2001;56(12):1746-8. doi: 10.1212/wnl.56.12.1746. PubMed PMID: 11425944. [doi] [pmid]
5. Mestre H, Tithof J, Du T, Song W, Peng W, Sweeney AM, Olveda G, Thomas JH, Nedergaard M, Kelley DH. Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension. Nat Commun. 2018;9(1):4878. Epub 20181119. doi: 10.1038/s41467-018-07318-3. PubMed PMID: 30451853; PMCID: PMC6242982. [doi] [pmid]
6. Yildiz S, Thyagaraj S, Jin N, Zhong X, Heidari Pahlavian S, Martin BA, Loth F, Oshinski J, Sabra KG. Quantifying the influence of respiration and cardiac pulsations on cerebrospinal fluid dynamics using real-time phase-contrast MRI. J Magn Reson Imaging. 2017;46(2):431-9. Epub 20170202. doi: 10.1002/jmri.25591. PubMed PMID: 28152239. [doi] [pmid]
7. Kollmeier JM, Gürbüz-Reiss L, Sahoo P, Badura S, Ellebracht B, Keck M, Gärtner J, Ludwig H-C, Frahm J, Dreha-Kulaczewski S. Deep breathing couples CSF and venous flow dynamics. Scientific Reports. 2022;12(1):2568. doi: 10.1038/s41598-022-06361-x. [doi]
8. Jin N, Simonetti OP. Free-Breathing Real-Time Flow Imaging using EPI and Shared Velocity Encoding. MAGNETOM Flash. 2013 01/2013:2.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/462-03-014