Synopsis
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369-05-011
ISMRM Abstract
Hyperpolarized 129Xe MRSI and RBC Oscillation Analysis for Assessing Pulmonary Embolism and Hyperoxic Vascular Response
Accepted
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1. Wendelboe AM, Raskob GE. Global Burden of Thrombosis. Circ Res. 2016;118(9):1340-1347. doi:10.1161/CIRCRESAHA.115.306841 [doi]
2. Schultz J, Andersen A, Gade IL, Ringgaard S, Kjaergaard B, Nielsen-Kudsk JE. A porcine in-vivo model of acute pulmonary embolism. Pulm Circ. 2018;8(1). doi:10.1177/2045893217738217 [doi]
3. Lyhne MD, Hansen JV, Dragsbæk SJ, Mortensen CS, Nielsen-Kudsk JE, Andersen A. Oxygen Therapy Lowers Right Ventricular Afterload in Experimental Acute Pulmonary Embolism. Crit Care Med. 2021;49(9):e891-e901. doi:10.1097/CCM.0000000000005057 [doi]
4. Wolber J, Cherubini A, Leach MO, Bifone A. Hyperpolarized129Xe NMR as a probe for blood oxygenation. Magn Reson Med. 2000;43(4):491-496. doi:10.1002/(SICI)1522-2594(200004)43:4<491::AID-MRM1>3.0.CO;2-6 [doi]
5. Wolber J, Cherubini A, Leach MO, Bifone A. On the oxygenation‐dependent 129Xe T 1 in blood. NMR Biomed. 2000;13(4):234-237. doi:10.1002/1099-1492(200006)13:4<234::aid-nbm632>3.3.co;2-b [doi]
6. Norquay G, Leung G, Stewart NJ, Wolber J, Wild JM. 129Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized 129Xe NMR. Magn Reson Med. 2017;77(4):1399-1408. doi:10.1002/mrm.26225 [doi]
7. Marshall H, Stewart NJ, Chan HF, Rao M, Norquay G, Wild JM. In vivo methods and applications of xenon-129 magnetic resonance. Prog Nucl Magn Reson Spectrosc. 2021;122:42. doi:10.1016/J.PNMRS.2020.11.002 [doi]
8. Hughes PJC, Horn FC, Collier GJ, Biancardi A, Marshall H, Wild JM. Spatial fuzzy c‐means thresholding for semiautomated calculation of percentage lung ventilated volume from hyperpolarized gas and 1H MRI. Journal of Magnetic Resonance Imaging. 2018;47(3):640-646. doi:10.1002/jmri.25804 [doi]
9. Tustison NJ, Altes TA, Qing K, et al. Image- vs. histogram-based considerations in semantic segmentation of pulmonary hyperpolarized gas images. March 2021. doi:10.1101/2021.03.04.21252588 [doi]
10. Vaeggemose M, Andersen M, Kristensen M, Hansen E, Laustsen C, Schulte R. Evaluating the acute response to oxygen using hyperpolarized 129-xenon dissolved-phase MRSI interleaved with global MRS in a porcine model. doi:10.58530/2025/0296 [doi]
11. Collier GJ, Schulte RF, Rao M, Norquay G, Ball J, Wild JM. Imaging gas‐exchange lung function and brain tissue uptake of hyperpolarized <scp> 129 Xe </scp> using sampling density‐weighted MRSI. Magn Reson Med. 2023;89(6):2217-2226. doi:10.1002/mrm.29602 [doi]
12. Purvis LAB, Clarke WT, Biasiolli L, Valkovič L, Robson MD, Rodgers CT. OXSA: An open-source magnetic resonance spectroscopy analysis toolbox in MATLAB. Motta A, ed. PLoS One. 2017;12(9):e0185356. doi:10.1371/journal.pone.0185356 [doi]
13. Vaeggemose M, Kristensen MH, Redda M, et al. MR Spectroscopic Imaging of Hyperpolarized 129‐Xenon in the Dissolved‐Phase to Determine Regional Chemical Shifts of Hyperoxia in Healthy Porcine Lungs. NMR Biomed. 2025;38(6). doi:10.1002/nbm.70063 [doi]
Cite this abstract
http://echo.ismrm.org/p/ISMRM2026/369-05-011