Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
661-04-010 ISMRM Abstract

Detecting Metabolic Heterogeneity within Leukodystrophy Patients using Unsupervised CEST Z-Spectral Analysis

Primary: Neuro - White Matter
Secondary: Analysis Methods - Segmentation and Detection
661-04-010 · AI-Based Analysis in MR Imaging · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row B
Keywords: White Matter Deep learning Anomaly Detection CEST MRI Leukodystrophy
Accepted
Abeer Mathur1, Anshuman Swain1, Paul S Jacobs1, neil wilson1, Narayan Datt Soni1, Dushyant Kumar1, Jennifer Orthman-Murphy2, Matthew Schindler2, Mohammad Haris1, Ravinder Reddy1
1Department of Radiology, Center for Advanced Metabolic Imaging in Precision Medicine (CAMIPM), University of Pennsylvania, Philadelphia, United States of America
2University of Pennsylvania, Philadelphia, United States of America
Presenting Author: Ari Borthakur

Synopsis

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References

1. Stellingwerff, M. D., Pouwels, P. J. W., Roosendaal, S. D., Barkhof, F., & van der Knaap, M. S. (2023). Quantitative MRI in leukodystrophies. NeuroImage: Clinical, 38, 103427.
2. van Zijl, P. C., & Yadav, N. N. (2011). Chemical exchange saturation transfer (CEST): what is in a name and what isn’t? Magnetic Resonance in Medicine, 65(4), 927–948.
3. Zhou, J., & van Zijl, P. C. M. (2006). Chemical exchange saturation transfer imaging and spectroscopy. Progress in Nuclear Magnetic Resonance Spectroscopy.
4. Kim, J., Wu, Y., Guo, Y., Zheng, H., & Sun, P. Z. (2015). A review of optimization and quantification techniques for CEST MRI toward sensitive in vivo imaging. Contrast Media & Molecular Imaging, 10(3), 163–178.
5. Swain, A., Jacobs, P., Mathur, A., & Reddy, R. (2025, May). Unsupervised AnomalyCEST: Unsupervised anomaly detection using CEST MRI of brain at 7T [Conference abstract]. In Proceedings of the 2025 ISMRM & ISMRT Annual Meeting & Exhibition (Abstract 4767), Honolulu, Hawaiʻi, USA, May 10–15, 2025.
6. Zhou, I. Y., Wang, E., Cheung, J. S., Zhang, X., Fulci, G., & Sun, P. Z. (2017). Quantitative CEST MRI of glioma using IDEAL fitting. Scientific Reports, 7(1), 84.
7. Windschuh, J., Zaiss, M., Meissner, J. E., Paech, D., Radbruch, A., Ladd, M. E., & Bachert, P. (2015). Correction of B1-inhomogeneities for relaxation-compensated CEST imaging at 7T. NMR in Biomedicine, 28(5), 529–537.
8. Jin, T., Wang, P., Zong, X., & Kim, S. G. (2013). MR imaging of the amide proton transfer effect and the pH-insensitive NOE effect in rat brain tumors. Magnetic Resonance in Medicine.
9. Kim M, Gillen J, Landman BA, Zhou J, van Zijl PC. Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments. Magn Reson Med. 2009 Jun;61(6):1441-50. doi: 10.1002/mrm.21873. PMID: 19358232; PMCID: PMC2860191. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/661-04-010