Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
605-03-007 ISMRM Abstract

Clinically feasible SANDI MRI for early identification of neurodegeneration in Alzheimer’s disease

Accepted
Hansol Lee 1,2, Jeremy N Ford3,4, Kwok-Shing Chan1, Hong Hsi Lee1, Susie Huang1
1Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, United States of America
2Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan, Korea, Republic of
3Harvard Medical School, Boston, United States of America
4Massachusetts General Hospital, Boston, United States of America
Presenting Author: Hansol Lee

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Jack Jr, C. R., Bennett, D. A., Blennow, K., Carrillo, M. C., Dunn, B., Haeberlein, S. B., ... & Silverberg, N. (2018). NIA‐AA research framework: toward a biological definition of Alzheimer's disease. Alzheimer's & dementia, 14(4), 535-562. PMID: 29653606 [pmid]
2. Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., ... & Trojanowski, J. Q. (2010). Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. The Lancet Neurology, 9(1), 119-128. PMID: 20083042 [pmid]
3. Chen, Y., Wang, Y., Song, Z., Fan, Y., Gao, T., & Tang, X. (2023). Abnormal white matter changes in Alzheimer's disease based on diffusion tensor imaging: A systematic review. Ageing Research Reviews, 87, 101911. PMID: 36931328 [pmid]
4. Kamagata, K., Andica, C., Hatano, T., Ogawa, T., Takeshige-Amano, H., Ogaki, K., ... & Aoki, S. (2020). Advanced diffusion magnetic resonance imaging in patients with Alzheimer's and Parkinson's diseases. Neural regeneration research, 15(9), 1590-1600. PMID: 32209758 [pmid]
5. Palombo, M., Ianus, A., Guerreri, M., Nunes, D., Alexander, D. C., Shemesh, N., & Zhang, H. (2020). SANDI: a compartment-based model for non-invasive apparent soma and neurite imaging by diffusion MRI. Neuroimage, 215, 116835. PMID: 32289460 [pmid]
6. Lee, H., Lee, H. H., Ma, Y., Eskandarian, L., Gaudet, K., Tian, Q., ... & Huang, S. Y. (2024). Age‐related alterations in human cortical microstructure across the lifespan: Insights from high‐gradient diffusion MRI. Aging Cell, 23(11), e14267. PMID: 39118344 [pmid]
7. Krijnen, E. A., Russo, A. W., Salim Karam, E., Lee, H., Chiang, F. L., Schoonheim, M. M., ... & Klawiter, E. C. (2023). Detection of grey matter microstructural substrates of neurodegeneration in multiple sclerosis. Brain Communications, 5(3), fcad153. PMID: 37274832 [pmid]
8. Ioakeimidis, V., Palombo, M., Casella, C., Layland, L., McNabb, C. B., Schubert, R., ... & Metzler-Baddeley, C. (2025). In vivo mapping of striatal neurodegeneration in Huntington’s disease with Soma and Neurite Density Imaging. medRxiv, 2025-03.  doi:10.1101/2025.03.17.25324107 [doi]
9. Barakovic, M., Weigel, M., Cagol, A., Schaedelin, S., Galbusera, R., Lu, P. J., ... & Granziera, C. (2024). A novel imaging marker of cortical “cellularity” in multiple sclerosis patients. Scientific reports, 14(1), 9848. PMID: 38684744 [pmid]
10. Margoni, M., Pagani, E., Preziosa, P., Palombo, M., Gueye, M., Azzimonti, M., ... & Rocca, M. A. (2023). In vivo quantification of brain soma and neurite density abnormalities in multiple sclerosis. Journal of Neurology, 270(1), 433-445. PMID: 36153468 [pmid]
11. Schiavi, S., Palombo, M., Zacà, D., Tazza, F., Lapucci, C., Castellan, L., ... & Inglese, M. (2023). Mapping tissue microstructure across the human brain on a clinical scanner with soma and neurite density image metrics. Human brain mapping, 44(13), 4792-4811. PMID: 37461286 [pmid]
12. Giordano, S. (2003). Effective medium theory for dispersions of dielectric ellipsoids. Journal of electrostatics, 58(1-2), 59-76. doi:10.1016/S0304-3886(02)00199-7 [doi]
13. Novikov, D. S., & Kiselev, V. G. (2010). Effective medium theory of a diffusion‐weighted signal. NMR in Biomedicine, 23(7), 682-697. PMID: 20886563 [pmid]
14. Lee, H.H., Abdollahzadeh, A., Lee, H., Coronado-Leija, R., Fieremans, E., Novikov, D.S., Huang, S.Y. (2026). Dependence of extra-cellular diffusion coefficient on the fractions of neurites and cell bodies in gray matter. ISMRM Annual Meeting (Submitted).
15. Fischl, B. (2012). FreeSurfer. Neuroimage, 62(2), 774-781. PMID: 22248573 [pmid]
16. Kellner, E., Dhital, B., Kiselev, V. G. and Reisert, M. (2016). Gibbs‐ringing artifact removal based on local subvoxel‐shifts. Magnetic resonance in medicine, 76(5), 1574-1581. doi:10.1002/mrm.26054. PMID: 26745823 [doi] [pmid]
17. Andersson J. L., Skare S. & Ashburner J. How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. Neuroimage 20, 870–888 (2003). PMID: 14568458 [pmid]
18. Andersson, J. L., & Sotiropoulos, S. N. (2016). An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage, 125, 1063-1078. PMID: 26481672 [pmid]
19. https://github.com/palombom/SANDI-Matlab-Toolbox-v1.0
20. Lee, H., Chan, K.S., Ma, Y., Krijnen E.A., Eskandarian, L., Bhatt, A., Gerold, J., Huang, S.Y., Lee, H.H., (2026). Clinical Soma and Neurite Density Imaging (SANDI): Translational microstructural mapping for standard 3T MRI scanners (Submitted).

Cite this abstract