Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
562-06-012 ISMRM Abstract

Osteocalcin-induced brain states shift from basic to "salient" and highlight its potential role in antidepressant strategies

Primary: Brain Function and fMRI - fMRI & Neuromodulation
Secondary: Preclinical Animal & in vitro MR - Small Animals
562-06-012 · fMRI: Preclinical · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row C
Keywords: Brain Connectivity fMRI (resting state) Neuroscience Cluster analysis Animal mouse model
Accepted
Natalia K Freus 1, Christian P Müller2, Andreas Hess1,3,4, Silke Kreitz1,3
1Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
2Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
3Institute of Neuroradiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
4FAU NeW – Research Center for New Bioactive Compounds, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany
Presenting Author: Natalia K Freus

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References

1. Oury, F. et al. Maternal and offspring pools of osteocalcin influence brain development and functions. Cell 155, 228–241; 10.1016/j.cell.2013.08.042 (2013). [doi]
2. Michelson, D. et al. Bone mineral density in women with depression. The New England journal of medicine 335, 1176–1181; 10.1056/NEJM199610173351602 (1996). [doi]
3. Altindag, O. et al. Relation of cortisol levels and bone mineral density among premenopausal women with major depression. International journal of clinical practice 61, 416–420; 10.1111/j.1742-1241.2006.01276.x (2007). [doi]
4. Kreitz, S. et al. A new analysis of resting state connectivity and graph theory reveals distinctive short-term modulations due to whisker stimulation in rats. Frontiers in neuroscience 12, 334; 10.3389/fnins.2018.00334 (2018). [doi]
5. Cordes, D. et al. Hierarchical clustering to measure connectivity in fMRI resting-state data. Magn Reson Imaging. May;20(4):305-17. 10.1016/s0730-725x(02)00503-9 (2002). [doi]
6. Freus, N.K., et al. Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression. Sci Rep 15, 10116. 10.1038/s41598-025-95000-2 (2025). [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/562-06-012