Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
551-02-015 / 551-02-015 ISMRM Abstract

Cingulate gradient dysfunction in ESRD and releated clinical phenotypes and underlying gene expression profiles

Primary: Brain Function and fMRI - fMRI Analysis
Secondary: Neuro - Other Neurodegeneration
551-02-015 · MRI of Renal Function · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
551-02-015 · MRI of Renal Function · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1
Keywords: fMRI (resting state) Gradients End-stage renal disease Allen Human Brain Atlas Cingulate
Accepted
Peng Li1,2, Junya Mu2, Ming Zhang 2, Wen Wang3
1Department of Medical Imaging, Nuclear Industry 215 Hospital of Shaanxi Province, Xianyang, China
2Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
3Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University, Xi'an, China
Presenting Author: Ming Zhang

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References

1. Viggiano, D. et al. Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol 16, 452-469, doi:10.1038/s41581-020-0266-9. [doi]
2. Zimmermann, S. et al. Chronic kidney disease leads to microglial potassium efflux and inflammasome activation in the brain. Kidney Int 106, 1101-1116, doi:10.1016/j.kint.2024.06.028. [doi]
3. Viggiano, D. et al. Mechanisms of cognitive dysfunction in CKD. Nat Rev Nephrol 16, 452-469, doi:10.1038/s41581-020-0266-9. [doi]
4. Scherer, J. S., Combs, S. A. & Brennan, F. Sleep Disorders, Restless Legs Syndrome, and Uremic Pruritus: Diagnosis and Treatment of Common Symptoms in Dialysis Patients. Am J Kidney Dis 69, 117-128, doi:10.1053/j.ajkd.2016.07.031. [doi]
5. Lambourg, E. et al. The prevalence of pain among patients with chronic kidney disease using systematic review and meta-analysis. Kidney Int 100, 636-649, doi:10.1016/j.kint.2021.03.041. [doi]
6. Gregg, L. P. et al. Fatigue in CKD: Epidemiology, Pathophysiology, and Treatment. Clin J Am Soc Nephrol 16, 1445-1455, doi:10.2215/CJN.19891220. [doi]
7. Flythe, J. E. et al. Symptom Prioritization among Adults Receiving In-Center Hemodialysis: A Mixed Methods Study. Clin J Am Soc Nephrol 13, 735-745, doi:10.2215/CJN.10850917. [doi]
8. Li, P. et al. Neurovascular coupling dysfunction in end-stage renal disease patients related to cognitive impairment. J Cereb Blood Flow Metab 41, 2593-2606, doi:10.1177/0271678X211007960. [doi]
9. Ni, L. et al. Aberrant default-mode functional connectivity in patients with end-stage renal disease: a resting-state functional MR imaging study. Radiology 271, 543-552, doi:10.1148/radiol.13130816. [doi]
10. Zhang, L. J. et al. Brain Default Mode Network Changes after Renal Transplantation: A Diffusion-Tensor Imaging and Resting-State Functional MR Imaging Study. Radiology 278, 485-495, doi:10.1148/radiol.2015150004. [doi]
11. Mu, J. et al. Altered white matter microstructure mediates the relationship between hemoglobin levels and cognitive control deficits in end-stage renal disease patients. Hum Brain Mapp 39, 4766-4775, doi:10.1002/hbm.24321. [doi]

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http://echo.ismrm.org/p/ISMRM2026/551-02-015