Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
352-03-011 / 352-03-011 ISMRM Abstract

Choroid Plexus Free-Water Diffusion Predicts Glymphatic Impairment and Clinical Severity in Parkinson's Disease

Primary: Neuro - Parkinson's Disease
Secondary: Diffusion - Microstructure
352-03-011 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
352-03-011 · Neurofluid Dynamics in Sleep and Disease · Monday, 11 May, 4:10 PM–5:46 PM · Power Pitch Theatre 2
Keywords: Choroid plexus Corpus callosum Glymphatic Function Free-water DTI model
Accepted
Suyi Zhou , Zhiming Zhen, Cheng Lai1, Zhentao Zuo1, Wei Chen2, Wei Chen
1State Key Laboratory of Cognitive Science and Mental Health, Chinese Academy of Sciences, Beijing, China
2MR Research Collaboration Team, Siemens Healthineers Ltd., Beijing, China
Presenting Author: Suyi Zhou

Synopsis

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References

1. Tadayon E, Pascual-Leone A, Press D, Santarnecchi E, Alzheimer’s Disease Neuroimaging Initiative. Choroid plexus volume is associated with levels of CSF proteins: Relevance for alzheimer’s and parkinson’s disease. Neurobiol Aging. 2020;89:108–17.
2. Yin X, Wang M, Zhao F, Li F, Tang Y, Wang X, et al. Choroid plexus area and choroid plexus /lateral ventricle area index are potential imaging markers for freezing of gait in parkinson’s disease. Neurobiol Dis. 2025;212:106984.
3. He P, Gao Y, Shi L, Li Y, Qiu Y, Feng S, et al. The association of CSF biomarkers and cognitive decline with choroid plexus volume in early parkinson’s disease. Parkinsonism Relat Disord. 2024;120:105987.
4. Velut S, Destrieux C, Kakou M. [morphologic anatomy of the corpus callosum]. Neurochirurgie. 1998;44:17–30.
5. Wei J, Liu Z, Su H, She Y, Wang J, Liu Y, et al. Subregional alterations in corpus callosum is associated with different symptoms in early-stage parkinson’s disease. Neurol Sci. 2025;46:2115–27.
6. Amandola M, Sinha A, Amandola MJ, Leung H-C. Longitudinal corpus callosum microstructural decline in early-stage parkinson’s disease in association with akinetic-rigid symptom severity. NPJ Parkinsons Dis. 2022;8:108.
7. Bledsoe IO, Stebbins GT, Merkitch D, Goldman JG. White matter abnormalities in the corpus callosum with cognitive impairment in Parkinson disease. Neurology. 2018;91:e2244–55.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/352-03-011