551-02-012 / 551-02-012 ISMRM Abstract

Progressive Worsening of White Matter Hyperintensity Burden Across Stages of Cardiovascular-Kidney-Metabolic Syndrome

Primary: Cross-Organ - White Matter

Secondary: Neuro - White Matter

551-02-012 · MRI of Renal Function · Wednesday, 13 May, 1:40 PM–3:16 PM · Power Pitch Theatre 1

Keywords: Magnetic Resonance Imaging (MRI) White Matter Hyperintensities Cerebral small vessel disease Cardiovascular-kidney-metabolic syndrome

Accepted

Jiayu Wu ^1,2,3,4, Jinping Lin^1,2,3,4, Bin Guo^1,2,3,4, Qiyong Gong^1,2,3,4

¹Huaxi MR Research Center (HMRRC), Institute of Radiology and Medical Imaging. West China Hospital of Sichuan University, Chengdu, Sichuan, China

²Psychoradiology Key Laboratory of Sichuan Province, West China Hospital of Sichuan University. Chengdu, Sichuan,China., China

³Research Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China

⁴Xiamen Key Lab of Psychoradiology and Neuromodulation, Department of Radiology, West China Xiamen Hospital of Sichuan University, Xiamen, Fujian, China

Presenting Author: Jiayu Wu

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References

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2. Tai XY, Veldsman M, Lyall DM, et al. Cardiometabolic multimorbidity, genetic risk, and dementia: a prospective cohort study. Lancet Healthy Longev. 2022;3(6):e428-e436. doi:10.1016/S2666-7568(22)00117-9IF: 14.6 Q1 [doi]

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4. Wang W, Zhang X, Lyu J, et al. Neuroimaging Findings From Cerebral Structure and Function in Coronary Artery Disease. J Magn Reson Imaging. 2025;61(5):2066-2082. doi:10.1002/jmri.29624 [doi]

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6. Evans LE, Taylor JL, Smith CJ, Pritchard HAT, Greenstein AS, Allan SM. Cardiovascular comorbidities, inflammation, and cerebral small vessel disease. Cardiovasc Res. 2021;117(13):2575-2588. doi:10.1093/cvr/cvab284 [doi]

7. Skrobot OA, Attems J, Esiri M, et al. Vascular cognitive impairment neuropathology guidelines (VCING): the contribution of cerebrovascular pathology to cognitive impairment. Brain. 2016;139(11):2957-2969. doi:10.1093/brain/aww214 [doi]

8. Simpson JE, Fernando MS, Clark L, et al. White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses. Neuropathol Appl Neurobiol. 2007;33(4):410-419. doi:10.1111/j.1365-2990.2007.00828.x [doi]

9. Kloppenborg RP, Nederkoorn PJ, Geerlings MI, van den Berg E. Presence and progression of white matter hyperintensities and cognition: a meta-analysis. Neurology. 2014;82(23):2127-2138. doi:10.1212/WNL.0000000000000505 [doi]

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http://echo.ismrm.org/p/ISMRM2026/551-02-012