Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
464-03-003 ISMRM Abstract

Stiff Person Syndrome Spectrum Disorders: A Multi-slice MR Spectroscopic Imaging Study

Primary: Neuro - Other Neurodegeneration
Secondary: Neuro - Neuroinflammation
464-03-003 · Neurodegenerative Diseases · Tuesday, 12 May, 1:40 PM–2:35 PM · Digital Posters Row E
Keywords: Other Neurodegeneration MR spectroscopy Neurometabolites 1H-MRSI Neurometabolic disorder
Accepted
Dillip K. Senapati 1, Scott D. Newsome2, Hanyeh Afshar2, Helge J Zöllner1, Peter B Barker1,3, Doris Lin1
1Russell H. Morgan Department of Radiology & Radiological Science, Russell H. Morgan Department of Radiology & Radiological Science, Baltimore, United States of America
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, United States of America
3F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States of America
Presenting Author: Dillip K. Senapati

Synopsis

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References

1. Newsome SD, Johnson T. Stiff person syndrome spectrum disorders; more than meets the eye. J Neuroimmunol. 2022;369:577915.
2. Wang Y, Hu C, Aljarallah S, et al. Expanding clinical profiles and prognostic markers in stiff person syndrome spectrum disorders. J Neurol. 2024;271(4):1861-1872.
3. Dalakas MC, Fujii M, Li M, McElroy B. The clinical spectrum of anti-GAD antibody- positive patients with stiff-person syndrome. Neurology. 2000;55(10):1531-1535.
4. Levy LM, Levy-Reis I, Fujii M, et al. Brain -Aminobutyric Acid Changes in Stiff-Person Syndrome. Arch Neurol 2005;62:970-974.
5. Zhu H, Ouwerkerk R, Barker PB. Dual-Band Water and Lipid Suppression for MR Spectroscopic Imaging at 3 Tesla. Magn. Reson Med. 2010; 63:1486–1492.
6. Zhu H, Edden RAE, Ouwerkerk R, Barker PB. High resolution spectroscopic imaging of GABA at 3 Tesla. Magn Reson Med. 2011;65(3):603-609.
7. Zöllner HJ, Senapati DK, Özdemir İ, et al. Reproducibility of metabolic mapping using 2D multi-slice short-TE and GABA-edited spin-echo MRSI at 3T in a single protocol. NMR in Biomed 2025 (in revision).
8. Oeltzschner G, Zöllner HJ, Hui SCN, et al. Osprey: Open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data. J Neurosci Methods. 2020;343:108827.
9. Chan KL, Barker PB. Retrospective motion compensation for edited MR spectroscopic imaging. NeuroImage. 2019;202:116141.
10. Zöllner HJ, Davies-Jenkins C, Simicic D, et al. Simultaneous multi-transient linear-combination modeling of MRS data improves uncertainty estimation. Magn Reson Med. 2024;92:916–925.
11. Hui SCN, Saleh MG, Zöllner HJ, et al. MRSCloud: A cloud-based MRS tool for basis set simulation. Magn Reson Med. 2022;88:1994–2004.

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/464-03-003