531-02-016 / 531-02-016 ISMRM Abstract

Postmortem Insights into CSF Diffusion Across Aging

Primary: Diffusion - Microstructure

Secondary: Neuro - Neurofluids

531-02-016 · Imaging Neurodegeneration in Motion: Multimodal Biomarkers for Alzheimer’s Disease and Parkinson’s Disease · Wednesday, 13 May, 1:40 PM–3:16 PM · Roof Terrace

Keywords: 7T Cerebrospinal fluid Age ADC Post-mortem

Accepted

Jose Henrique Monteiro de Azevedo^1,2, Khallil T Chaim³, Maria Garcia Otaduy^3,4,5, Carlos Salmon ^6,7

¹Inbrain lab, Faculty of Philosophy, Sciences and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirão Preto, Brazil, Brazil

²Ribeirão Preto Medical School, University of Sao Paulo, Ribeirão Preto, Brazil

³University of Sao Paulo, Ribeirao Preto, Brazil

⁴Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil

⁵LIM44-Instituto de Radiologia, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil

⁶Departamento de Física, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Brazil, Ribeirão Preto, Brazil

⁷Medical Images, Oncology and Hematology, Ribeirao Preto Medical School - University of Sao Paulo, Brazil

Presenting Author: Carlos Salmon

Synopsis

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References

1. Brown PD, Davies SL, Speake T, Millar ID. Molecular mechanisms of cerebrospinal fluid production. Neuroscience. 2004;129(4):957-70. https://doi.org/10.1016/j.neuroscience.2004.07.003 [doi]

2. Verbeek MM, De Jong D, Kremer HP. Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases. Ann Clin Biochem. 2003 Jan;40(Pt 1):25-40. https://doi.org/10.1258/000456303321016141 [doi]

3. Sasaki M, Yamada K, Watanabe Y, Matsui M, Ida M, Fujiwara S, Shibata E; Acute Stroke Imaging Standardization Group-Japan (ASIST-Japan) Investigators. Variability in absolute apparent diffusion coefficient values across different platforms may be substantial: a multivendor, multi-institutional comparison study. Radiology. 2008 Nov;249(2):624-30. https://doi.org/10.1148/radiol.2492071681 [doi]

4. Kozak LR, Bango M, Szabo M, Rudas G, Vidnyanszky Z, Nagy Z. Using diffusion MRI for measuring the temperature of cerebrospinal fluid within the lateral ventricles. Acta Paediatr. 2010 Feb;99(2):237-43. https://doi.org/10.1111/j.1651-2227.2009.01528.x [doi]

5. R. Mills. Self-diffusion in normal and heavy water in the range 1-45.deg. The Journal of Physical Chemistry 1973 77 (5), 685-688. https://doi.org/10.1021/j100624a025 [doi]

6. Koleske JP, Pan S, Meehan T, Loe M, Morales DM, Lucey BP, Musiek E, Strahle JM. Time-of-day and age-related patterns in cerebrospinal fluid glucose and protein. Fluids Barriers CNS. 2025 Oct 16;22(1):102. https://doi.org/10.1186/s12987-025-00686-1 [doi]

7. Farinas A, Rutledge J, Bot VA, Western D, Ying K, Lawrence KA, Oh HS, Yoon S, Ding DY, Tsai AP, Moran-Losada P, Timsina J, Le Guen Y; Global Neurodegeneration Proteomics Consortium (GNPC); Montgomery SB, Baker D, Poston KL, Wagner AD, Mormino E, Cruchaga C, Wyss-Coray T. Disruption of the cerebrospinal fluid-plasma protein balance in cognitive impairment and aging. Nat Med. 2025 Aug;31(8):2578-2589. https://doi.org/10.1038/s41591-025-03831-3 [doi]

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http://echo.ismrm.org/p/ISMRM2026/531-02-016