Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
408-04-007 ISMRM Abstract

Novel Quantum-Sensing Hyperpolarized 13C Molecular MR Fingerprinting Applications in Abdominal and Pelvic Cancers

Primary: Acquisition & Reconstruction - Quantitative Imaging: relaxometry, multi-parametric, MR Fingerprinting, and synthetic MRI
Secondary: Body - Pancreas
408-04-007 · Quantitative Imaging: MR Fingerprinting · Tuesday, 12 May, 4:00 PM–5:50 PM · Meeting Room 1.60
Keywords: MR Fingerprinting Pancreatic cancer Renal cell carcinoma Prostate cancer Hyperpolarized 13C MRI
Accepted
Hsin-Yu Chen1, Charlie Wang 2, Minjie Zhu2, Daniel T Gebrezgiabhier1, Michael Ohliger2,3,4,5,6, Xiaoxi Lui1, Ivan de Kouchkovsky7, John Kurhanewicz2,8, Robert Bok2, Rahul Aggarwal7, Peder Larson2, Jeremy W Gordon2, Zhen J Wang2,6, Dan Vigneron2,9,10
1Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, United States of America
2Department of Radiology and Biomedical Imaging, University Of California, San Francisco (UCSF), United States of America
3Radiology, University of California San Francisco, San Francisco, United States of America
4Radiology, University Of California, San Francisco (UCSF), United States of America
5Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, United States of America
6University of California San Francisco, San Francisco, United States of America
7Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, United States of America
8University Of California, San Francisco (UCSF), United States of America
9UCSF, San Francisco, United States of America
10Department of Neurological Surgery, University Of California, San Francisco (UCSF), United States of America
Presenting Author: Charlie Wang

Synopsis

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References

1. Chen HY et al., Improving multiparametric MR-transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13C pyruvate metabolic imaging: A technical development study. Magn Reson Med. 2022; 88(6), 2609-2620 doi:10.1002/mrm.29399 [doi]
2. de Kouchkovsky I et al., Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer. J Magn Reson Open. 2024; 100165 doi:10.1016/j.jmro.2024.100165 [doi]
3. Chen HY et al., Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. Prostate Cancer Prostatic Dis. 2020; 23(2), 269-276 doi:10.1038/s41391-019-0180-z [doi]
4. Sushentsev N et al., Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer. Nat Commun. 2022; 13(1), 466 doi:10.1038/s41467-022-28069-2 [doi]
5. Chen HY et al., Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI-A Correlative Study with Clinical Outcomes. Cancers 2025; 17 (13), 2211 doi:10.3390/cancers17132211 [doi]
6. Larson PEZ et al., Current methods for hyperpolarized [1-13C]pyruvate MRI human studies. Magn Reson Med. 2024; 91(6), 2204-2228 doi:10.1002/mrm.29875 [doi]
7. Lee PM et al., Whole‐abdomen metabolic imaging of healthy volunteers using hyperpolarized [1‐13C] pyruvate MRI. J. Magn. Reson. Imaging. 2022; 56(6), 1792-1806 doi:10.1002/jmri.28196 [doi]
8. Tang S et al., A metabolite‐specific 3D stack‐of‐spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1‐13C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020; 84(3), 1113-1125 doi:10.1002/mrm.28204 [doi]
9. Haller AB et al., A flexible MRF approach to improve kinetic rate estimation with bSSFP‐based hyperpolarized [1‐13C]pyruvate MRI. Magn Reson Med. 2025; 93(6), 2263-2277 doi:10.1002/mrm.30466 [doi]
10. Gordon JW et al., Hyperpolarized 13C Metabolic MRI of Patients with Pancreatic Ductal Adenocarcinoma. J. Magn. Reson. Imaging. 2024; 60(2), 741-749 doi:10.1002/jmri.29162 [doi]
11. Ursprung S et al., Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study. Cancers 2022; 14(2), 335 doi:10.3390/cancers14020335 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/408-04-007