Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
469-05-008 ISMRM Abstract

7T 31P MT-ISIS for Quantifying CK and ATPase in Human Skeletal Muscle

Primary: Contrast Mechanisms - Non-Proton
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
469-05-008 · Non-Proton MRI: Methods and Applications · Tuesday, 12 May, 4:00 PM–4:55 PM · Digital Posters Row J
Keywords: Energy metabolism Phosphorus-31 Magnetization transfer (MT) ISIS localization
Accepted
Ying-Hua Chu1, Caixia Fu2, Wenwen Yu3, He Wang3, Yi-Cheng Hsu1
1MR Research Collaboration Team, Shanghai, China
2MR Application Development, Siemens Shenzhen Magnetic Resonance Ltd., Shenzhen, China
3Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China
Presenting Author: Jianxun Qu

Synopsis

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References

1. Du, Fei, Xiao‐Hong Zhu, Hongyan Qiao, Xiaoliang Zhang, and Wei Chen. "Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain." Magnetic Resonance in Medicine: An Official Journal of the International Society for Magnetic Resonance in Medicine 57, no. 1 (2007): 103-114.
2. Xiong, Qiang, Fei Du, Xiaohong Zhu, Pengyuan Zhang, Piradeep Suntharalingam, Joseph Ippolito, Forum D. Kamdar, Wei Chen, and Jianyi Zhang. "ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method." Circulation research 108, no. 6 (2011): 653-663.
3. Tannús, Alberto, and Michael Garwood. "Adiabatic pulses." NMR in Biomedicine: An International Journal Devoted to the Development and Application of Magnetic Resonance In Vivo 10, no. 8 (1997): 423-434.
4. Naressi A, Couturier C, Devos JM, Janssen M, Mangeat C, de Beer R, et al. Java-based graphical user interface for the MRUI quantitation package. MAGMA. 2001;12:141–52. pmid:11390270 [pmid]
5. Vanhamme L, Van Huffel S, Van Hecke P, van Ormondt D. Time-domain quantification of series of biomedical magnetic resonance spectroscopy signals. J Magn Reson. 1999;140(1):120–30. pmid:10479554 [pmid]
6. Ryan, Terence E., Melissa L. Erickson, Ajay Verma, Juan Chavez, Michael H. Rivner, and Kevin K. Mccully. "Skeletal muscle oxidative capacity in amyotrophic lateral sclerosis." Muscle & nerve 50, no. 5 (2014): 767-774.
7. Ren, Jimin, A. Dean Sherry, and Craig R. Malloy. "Amplification of the effects of magnetization exchange by 31P band inversion for measuring adenosine triphosphate synthesis rates in human skeletal muscle." Magnetic resonance in medicine 74, no. 6 (2015): 1505-1514.
8. Parasoglou, Prodromos, Ding Xia, Gregory Chang, and Ravinder R. Regatte. "3D‐mapping of phosphocreatine concentration in the human calf muscle at 7 T: comparison to 3 T." Magnetic Resonance in Medicine 70, no. 6 (2013): 1619-1625.

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http://echo.ismrm.org/p/ISMRM2026/469-05-008