Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
569-02-006 ISMRM Abstract

In Vivo 31P-MRS Reveals APOE4-Linked Metabolic Vulnerability in Hippocampus

Primary: Neuro - Alzheimer's Disease
Secondary: Acquisition & Reconstruction - Spectroscopy and spectroscopic imaging
569-02-006 · Novel Pulse Sequences and Reconstruction Strategies · Wednesday, 13 May, 9:15 AM–10:10 AM · Digital Posters Row J
Keywords: 31P-MRSI
Accepted
Qianyun Su1,2, Qiurong Yu1,2, Xinyan Li1,2, Xi Wang3, Ruixi Li1,2, Jinyuan Weng4, Peng Wu 4, Yuxiang Teng1,2, Yixin Zhou1,2, Naying He2, Jianfang Ma3, Fuhua Yan1,2
1College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China
2Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
3Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China
4Clinical and Technical Support, Philips Healthcare (Beijing), Beijing, China
Presenting Author: Peng Wu

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References

1. Pini L, Pievani M, Bocchetta M, Altomare D, Bosco P, Cavedo E, Galluzzi S, Marizzoni M, Frisoni GB. Brain atrophy in Alzheimer's Disease and aging. Ageing Res Rev. 2016 Sep;30:25-48. doi: 10.1016/j.arr.2016.01.002. Epub 2016 Jan 28. PMID: 26827786. [doi] [pmid]
2. Petrie EC, Cross DJ, Galasko D, Schellenberg GD, Raskind MA, Peskind ER, Minoshima S. Preclinical evidence of Alzheimer changes: convergent cerebrospinal fluid biomarker and fluorodeoxyglucose positron emission tomography findings. Arch Neurol. 2009 May;66(5):632-7. doi: 10.1001/archneurol.2009.59. PMID: 19433663; PMCID: PMC2718788. [doi] [pmid]
3. Fortea J, Pegueroles J, Alcolea D, Belbin O, Dols-Icardo O, Vaqué-Alcázar L, Videla L, Gispert JD, Suárez-Calvet M, Johnson SC, Sperling R, Bejanin A, Lleó A, Montal V. APOE4 homozygozity represents a distinct genetic form of Alzheimer's disease. Nat Med. 2024 May;30(5):1284-1291. doi: 10.1038/s41591-024-02931-w. Epub 2024 May 6. Erratum in: Nat Med. 2024 Jul;30(7):2093. doi: 10.1038/s41591-024-03127-y. PMID: 38710950. [doi] [pmid]
4. Stefan D , Cesare F D , Andrasescu A ,et al.Quantitation of Magnetic Resonance Signals: The jMRUI Software Package[J].Measurement ence & Technology, 2009, 20(10):251-252.DOI:10.1088/0957-0233/20/10/104035. [doi]
5. Shivu GN, Abozguia K, Phan TT, Ahmed I, Henning A, Frenneaux M. (31)P magnetic resonance spectroscopy to measure in vivo cardiac energetics in normal myocardium and hypertrophic cardiomyopathy: Experiences at 3T. Eur J Radiol. 2010 Feb;73(2):255-9. doi: 10.1016/j.ejrad.2008.10.018. Epub 2008 Dec 3. PMID: 19056193. [doi] [pmid]

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http://echo.ismrm.org/p/ISMRM2026/569-02-006