Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
302-04-005 ISMRM Abstract

2D Biomechanical fingerprinting of liver disease identifies a pre-fibrotic niche permissive for HCC development

Primary: Body - Liver
Secondary: Analysis Methods - Data Processing
302-04-005 · Mapping Liver and Pancreas Health · Monday, 11 May, 4:10 PM–6:00 PM · Hall 1B
Keywords: 3D Magnetic Resonance Elastography Biomechanical Fingerprinting Liver Disease Progression Inflammation and Fibrosis Early Cancer Risk Stratification
Accepted
Gabrielle Mangin 1, Leon D Gruenewald2, Nicole S Ziegengeist2, Katerina Torgashov2, Omar I Darwish3,4, Giacomo Annio1, Valérie Paradis1,5, Jerome Boursier6, Valerie Vilgrain1,7, Thomas J Vogl2,8, Vitali Koch2, Ralph Sinkus1
1Center for Research on Inflammation, Inserm / Université Paris Cité U1149, Paris, France
2Goethe University Frankfurt, University Hospital, Frankfurt, Germany
3Magnetic Resonance, Siemens Healthineers AG, Erlangen, Germany
4Imaging Physics and Engineering Research Department, School of Biomedical Engineering & Imaging Sciences, Kings College London, London, United Kingdom
5Histology department, Hopital Beaujon, APHP, Clichy, France
6CHU d'Angers, Angers, France
7Hopital Beaujon, APHP, Clichy, France
8University Hospital Frankfurt, Frankfurt am Main, Germany
Presenting Author: Gabrielle Mangin

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. The Lancet. Reversing the rise of liver cancer. Lancet. 2025 Aug 16;406(10504):665. doi: 10.1016/S0140-6736(25)01530-2. Epub 2025 Jul 28. PMID: 40744049. [doi] [pmid]
2. The Lancet Commission on addressing the global hepatocellular carcinoma burden: comprehensive strategies from prevention to treatment, Chan, Stephen Lam et al. The Lancet, Volume 406, Issue 10504, 731 - 778
3. Koch V, et.al. Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic MR Elastography. J Magn Reson Imaging. 2025 Apr;61(4):1890-1904. doi: 10.1002/jmri.29560. Epub 2024 Aug 21. PMID: 39165139; PMCID: PMC11896941. [doi] [pmid]
4. Guenthner C, Sethi S, Troelstra M, Dokumaci AS, Sinkus R, Kozerke S. Ristretto MRE: A generalized multi-shot GRE-MRE sequence. NMR Biomed. 2019 May;32(5):e4049. doi: 10.1002/nbm.4049. Epub 2019 Jan 29. PMID: 30697827; PMCID: PMC6590281. [doi] [pmid]
5. Annio G, et.al. Making sense of scattering: Seeing microstructure through shear waves. Sci Adv. 2024 Aug 2;10(31):eadp3363. doi: 10.1126/sciadv.adp3363. Epub 2024 Jul 31. PMID: 39083612; PMCID: PMC11290519. [doi] [pmid]
6. Fan W, et.al. Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver. Nature. 2024 Feb;626(7999):635-642. doi: 10.1038/s41586-023-06991-9. Epub 2024 Jan 31. PMID: 38297127; PMCID: PMC10866704. [doi] [pmid]
7. Salameh N, et al. Early detection of steatohepatitis in fatty rat liver by using MR elastography. Radiology. 2009 Oct;253(1):90-7. doi: 10.1148/radiol.2523081817. Epub 2009 Jul 8. PMID: 19587308. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/302-04-005