Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
563-06-002 ISMRM Abstract

Does APT-weighted CEST MRI depend on protein and amide proton content in human brain tumor?

Primary: Neuro - Tumors
Secondary: Contrast Mechanisms - CEST / APT / NOE
563-06-002 · From Molecular Signatures to Surgical Guidance: Cutting-Edge MRI in Brain Tumor Care · Wednesday, 13 May, 4:55 PM–5:50 PM · Digital Posters Row D
Keywords: Brain Tumor Imaging Amide proton transfer-weighted imaging Chemical Exchange Saturation Transfer (CEST) MRI
Accepted
Yulun Wu1, Rick N Bezemer1, Tobias Wood2, Thomas C Booth3,4, Matthew Benger3, Caitlin O'Brien5, Keyoumars Ashkan6, Fatemeh Arzanforoosh7, Amina Avan1, Lennard J Dekker8, Sophie E Veldhuijzen van Zanten1,9,10, Ilanah J Pruis10,11, Eelke M Bos12, Joost W Schouten12, Arnaud J Vincent12, Marion Smits1,9,10, Theo Luider8, Esther Warnert 1,10
1Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
2Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom
3Department of Neuroradiology, King's College Hospital NHS Foundation Trust London, London, United Kingdom
4School of Biomedical Engineering & Imaging Sciences, King's College London, London, United Kingdom
5Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom
6Department of Neurosurgery, King's College Hospital NHS Foundation Trust London, London, United Kingdom
7Department of Radiation Oncology, University Medical Center Groningen, Groningen, Netherlands
8Department of Neurology, Erasmus MC, Rotterdam, Netherlands
9Medical Delta, Delft, Netherlands
10Brain Tumor Center, Erasmus MC Cancer Institute, Rotterdam, Netherlands
11Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands
12Department of Neurosurgery, Erasmus MC, Rotterdam, Netherlands
Presenting Author: Esther Warnert

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References

1. 1. Sotirios, B., et al., The role of APT imaging in gliomas grading: A systematic review and meta-analysis. Eur J Radiol, 2020. 133: p. 109353. https://doi.org/10.1016/j.ejrad.2020.109353 [doi]
2. 2. Zhou, J., et al., Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors. Magn Reson Med, 2022. 88(2): p. 546-574. https://doi.org/10.1002/mrm.29241 [doi]
3. 3. Deshmane, A., et al., 3D gradient echo snapshot CEST MRI with low power saturation for human studies at 3T. Magnetic Resonance in Medicine, 2019. 81(4): p. 2412-2423. https://doi.org/10.1002/mrm.27569 [doi]
4. 4. Wu, Y., et al., 3D APT and NOE CEST-MRI of healthy volunteers and patients with non-enhancing glioma at 3 T. Magnetic Resonance Materials in Physics, Biology and Medicine, 2022. https://doi.org/10.1007/s10334-021-00996-z [doi]
5. 5. UniProt, C., UniProt: the universal protein knowledgebase in 2021. Nucleic Acids Res, 2021. 49(D1): p. D480-D489. https://doi.org/10.1093/nar/gkaa1100 [doi]

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http://echo.ismrm.org/p/ISMRM2026/563-06-002