Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
363-06-007 ISMRM Abstract

Dampened Limbic and Striatal Pulsatility in Idiopathic Intracranial Hypertension: Insights from q-aMRI and Flow MRI

Primary: Neuro - Neurofluids
Secondary: Analysis Methods - Data Processing
363-06-007 · Hemodynamics and Flow · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row D
Keywords: Quantitative MRI Cerebrospinal fluid flow Cerebral blood flow (CBF) Idiopathic intracranial hypertension Intracranial pressure
Accepted
Jet Wright1,2, Sergio Dempsey1,3, Alireza Sharifzadeh-Kermani1,2, Paul M Condron1,4,5, Matthew McDonald1,6, Sarah-Jane Guild5, Graham Wilson1,7, David Dubowitz5,8, Miriam Scadeng5, Leigh Potter1, Daniel Cornfeld1,5, Itamar Terem9, Eryn Kwon1,2, Helen Danesh-Meyer1,5,10,11, Gonzalo Maso Talou2, Samantha Holdsworth 1,2,5, Vickie Shim1,2
1Mātai Medical Research Institute, Gisborne, New Zealand
2Auckland Bioengineering Institute, University of Auckland, Auckland, New Zealand
3GE HealthCare, Gisborne, New Zealand
4MRI, Mātai Medical Research Institute, Gisborne, New Zealand
5University of Auckland, Auckland, New Zealand
6Te Whatu Ora Health New Zealand, New Zealand
7University of Otago, Christchurch, New Zealand
8Centre of Advanced MRI (CAMRI), University of Auckland, Auckland, New Zealand
9Electrical Engineering, Stanford University, Stanford, United States of America
10Eye Institute, Auckland, New Zealand
11Vision Research Foundation, University of Auckland, Auckland, New Zealand
Presenting Author: Samantha Holdsworth

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Wakerley BR, Mollan SP, Sinclair AJ. Idiopathic intracranial hypertension: Update on diagnosis and management. Clin Med (Lond). 2020;20(4):384–388. https:/doi.org/10.7861/clinmed.2020-0232 [doi]
2. Monro A. Observations on the Structure and Functions of the Nervous System, Illustrated with Tables. Lond Med J. 1783;4(2):113-35. PMCID: PMC5545466
3. Kellie G. An Account of the Appearances Observed in the Dissection of Two of Three Individuals Presumed to Have Perished in the Storm of the3d, and Whose Bodies Were Discovered in the Vicinity of Leith on the Morning of the 4th, November 1821; with Some Reflections on the Pathology of the Brain: Part I. Trans Med Chir Soc Edinb. 1824;1:84-122. PMID: 29583621 [pmid]
4. Benson JC, Madhavan AA, Cutsforth-Gregory JK, Johnson DR, Carr CM. The Monro-Kellie Doctrine: A Review and Call for Revision. AJNR Am J Neuroradiol. 2023;44(1):2-6. https:/doi.org/10.3174/ajnr.A7721 [doi]
5. Terem I, Younes K, Wang N, Condron P, Abderezaei J, Kumar H, et al. 3D Quantitative-Amplified Magnetic Resonance Imaging (3D q-aMRI). Bioengineering [Internet]. 2024; 11(8). https:/doi.org/10.3390/bioengineering11080851 [doi]
6. Abderezaei J, Pionteck A, Terem I, Dang L, Scadeng M, Morgenstern P, et al. Development, calibration, and testing of 3D amplified MRI (aMRI) for the quantification of intrinsic brain motion. Brain Multiphysics. 2021;2:100022. https://doi.org/10.1016/j.brain.2021.100022 [doi]
7. Holdsworth SJ, Rahimi MS, Ni WW, Zaharchuk G, Moseley ME. Amplified magnetic resonance imaging (aMRI). Magnetic Resonance in Medicine.2016;75(6):2245-54. https:/doi.org/10.1002/mrm.26142 [doi]
8. Terem I, Dang L, Champagne A, Abderezaei J, Pionteck A, Almadan Z, et al. 3D amplified MRI (aMRI). Magn Reson Med. 2021;86(3):1674-86. https:/doi.org/10.1002/mrm.28797 [doi]
9. Terem I, Ni WW, Goubran M, Rahimi MS, Zaharchuk G, Yeom KW, et al. Revealing sub-voxel motions of brain tissue using phase-based amplified MRI (aMRI). Magn Reson Med. 2018;80(6):2549-59. https:/doi.org/10.1002/mrm.27236 [doi]
10. Enzmann DR, Pelc NJ. Brain motion: measurement with phase-contrast MR imaging. Radiology. 1992;185(3):653-60. https:/doi.org/10.1148/radiology.185.3.1438741 [doi]
11. Greitz D, Wirestam R, Franck A, Nordell B, Thomsen C, Ståhlberg F. Pulsatile brain movement and associated hydrodynamics studied by magnetic resonance phase imaging. The Monro-Kellie doctrine revisited. Neuroradiology. 1992;34(5):370-80. https:/doi.org/10.1007/BF00596493 [doi]
12. Feinberg DA, Mark AS. Human brain motion and cerebrospinal fluid circulation demonstrated with MR velocity imaging. Radiology.1987;163(3):793-9. https:/doi.org/10.1148/radiology.163.3.3575734 [doi]
13. Poncelet BP, Wedeen VJ, Weisskoff RM, Cohen MS. Brain parenchyma motion: measurement with cine echo-planar MR imaging. Radiology.1992;185(3):645-51. https:/doi.org/10.1148/radiology.185.3.1438740 [doi]
14. Roberts GS, Hoffman CA, Rivera-Rivera LA, Berman SE, Eisenmenger LB, Wieben O. Automated hemodynamic assessment for cranial 4D flow MRI. Magn Reson Imaging. 2023;97:46-55. https:/doi.org/10.1016/j.mri.2022.12.016 [doi]
15. Dempsey S, Safaei S, Holdsworth SJ, Talou GDM. Measuring global cerebrovascular pulsatility transmission using 4D flow MRI. Scientific Reports.2024;14(1):12604. https:/doi.org/10.1038/s41598-024-63312-4 [doi]
16. Dempsey S, Safaei S, Holdsworth SJ, Maso Talou GD. Intracranial pulse wave velocity using 4D flow MRI: method comparison and covariate analysis. Interface Focus. 2025;15(1):20240036. https:/doi.org/10.1098/rsfs.2024.0036 [doi]
17. Billot B, Greve DN, Puonti O, Thielscher A, Van Leemput K, Fischl B, et al. SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining. Medical Image Analysis. 2023;86:102789. https:/doi.org/10.1016/j.media.2023.102789 [doi]
18. Bateman GA. A scoping review of the discrepancies in the measurement of cerebral blood flow in idiopathic intracranial hypertension: oligemia, euvolemia or hyperemia? Fluids Barriers CNS. 2023;20(1):63. https://doi.org/10.1186/s12987-023-00465-w [doi]
19. Grech O, Clouter A, Mitchell JL, Alimajstorovic Z, Ottridge RS, Yiangou A, et al. Cognitive performance in idiopathic intracranial hypertension and relevance of intracranial pressure. Brain Commun. 2021;3(3):fcab202. https://doi.org/10.1093/braincomms/fcab202 [doi]
20. Paranathala MP, Yoganathan KT, Mitchell P, Williams IA, Gourley L, Coulter IC. The psychological and cognitive landscape of adult idiopathic intracranial hypertension: A scoping review. Neurol Clin Pract. 2024;14(6):e200348. https://doi.org/10.1212/CPJ.0000000000200348 [doi]
21. Hulens M, Rasschaert R, Vansant G, Stalmans I, Bruyninckx F, Dankaerts W. The link between idiopathic intracranial hypertension, fibromyalgia, and chronic fatigue syndrome: Exploration of a shared pathophysiology. J Pain Res. 2018;11:3129-3140. https://doi.org/10.2147/JPR.S186878 [doi]
22. Cerqueira JJ, Sousa N. Executive function in striatal disorders. In: Goldberg E, ed. Executive Functions in Health and Disease. Academic Press; 2017:301-317. https://doi.org/10.1016/B978-0-12-803676-1.00012-X [doi]
23. Rajmohan V, Mohandas E. The limbic system. Indian J Psychiatry. 2007;49(2):132-139. https://doi.org/10.4103/0019-5545.33264 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/363-06-007