Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
369-06-016 ISMRM Abstract

MR safety framework enabling "in-MRI' catheter trajectory planning & putaminal gene therapy with non MR-conditional equipment

Primary: Physics & Engineering - Safety
Secondary: Interventional - MR-Guided Interventions
369-06-016 · Advances in Interventional MRI: Guidance, Motion Management, and Precision Treatment Technologies · Monday, 11 May, 5:05 PM–6:00 PM · Digital Posters Row J
Keywords: MR-Guided Interventions Safety Neurosurgery MR Physics
Accepted
Enrico De Vita1,2, Marta Calado3, Hannah Brain3, Kristian Aquilina3, Martin Tisdall3, Ravi Shihurkar3, Marco Borri4, Matthew Rabon5, Jane Hassell6, Elena Fernandez3, Manju Kurian6, Lucinda Carr6, Annemarie Knill1, Kelly Rea7, Fernaiza Sahidjuan7, Kristijan Ristovic7, Sari Tenho7, Monal Patel7, Dinushi Mahamayagodage7, Fatima Odususi7, Jessica Cooper8
1MR Physics Group. Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
2Developmental Imaging and Biophysics Unit. Department of Developmental Neuroscience, UCL Great Ormond Street Institute of Child Health, London, United Kingdom
3Neurosurgery, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
4Medical Engineering and Physics, King's College Hospital NHS Foundation Trust London, London, United Kingdom
5ClearPoint Neuro, Inc, Solana Beach, United States of America
6Neurology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
7Radiology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom
8Radiology, Great Ormond Street Hospital, London, United Kingdom
Presenting Author: Yi Jie Li

Synopsis

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References

1. Bergkvist, M., Stephens, C., Schilling, T., Wang, A., Yu, X., Goodwin, E., … Klein, M. (2022). Aromatic L-amino acid decarboxylase deficiency: a systematic review. Future Neurology, 17(4). https://doi.org/10.2217/fnl-2022-0012 [doi]
2. Simons CL, Hwu WL, Zhang R, Simons MJHG, Bergkvist M, Bennison C. Long-Term Outcomes of Eladocagene Exuparvovec Compared with Standard of Care in Aromatic L-Amino Acid Decarboxylase (AADC) Deficiency: A Modelling Study. Adv Ther. 2023 Dec;40(12):5399-5414. doi: 10.1007/s12325-023-02689-6. Epub 2023 Oct 6. PMID: 37803205; PMCID: PMC10611606. [doi] [pmid]
3. https://www.nice.org.uk/guidance/hst26/resources/eladocagene-exuparvovec-for-treating-aromatic-lamino-acid-decarboxylase-deficiency-pdf-50216322673861
4. SURGICAL GUIDE, Upstaza (eladocagene exuparvovec), Version 2.0, accessed 30 Oct 2025: https://www.medicines.org.uk/emc/rmm/100418/Document
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6. Mohyeldin A, Lonser RR, Elder JB. Real-time magnetic resonance imaging-guided frameless stereotactic brain biopsy: technical note. J Neurosurg. 2016 Apr;124(4):1039-46. doi: 10.3171/2015.5.JNS1589. Epub 2015 Oct 23. PMID: 26495951. [doi] [pmid]
7. Scheer JK, Hamelin T, Chang L, Lemkuil B, Carter BS, Chen CC. Real-time Magnetic Resonance Imaging-Guided Biopsy Using SmartFrame® Stereotaxis in the Setting of a Conventional Diagnostic Magnetic Resonance Imaging Suite. Oper Neurosurg. 2017 Jun 1;13(3):329-337. doi: 10.1093/ons/opw035. PMID: 28521346. [doi] [pmid]
8. Lombardi S, Tortora D, Picariello S, Sudhakar S, De Vita E, Mankad K, Varadkar S, Consales A, Nobili L, Cooper J, Tisdall MM, D'Arco F. Intraoperative MRI Assessment of the Tissue Damage during Laser Ablation of Hypothalamic Hamartoma. Diagnostics (Basel). 2023 Jul 10;13(14):2331. doi: 10.3390/diagnostics13142331. PMID: 37510075; PMCID: PMC10378573. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/369-06-016