Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
666-03-014 ISMRM Abstract

Sex-specific structural and metabolic changes in the mouse brain induced by ketogenic diet

Primary: Preclinical Animal & in vitro MR - Biomarkers
Secondary: Neuro - Psychiatric Disorders
666-03-014 · Neuro-Biomarkers · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row G
Keywords: MRS Animal mouse model Voxel-Based Morphometry (VBM) Ketogenic
Accepted
Wolfgang Weber-Fahr 1,2, Claudia Falfán-Melgoza1, Anne Mallien3, Markus Sack2, Gabriele Ende2, Peter Gass3, Alexander Sartorius1,4, Ilya Smolensky5,6,7, Dragos Inta5,6,7
1RG Translational Imaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
2Department Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
3RG Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
4Dept. of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
5Dep. for Community Health, University of Fribourg, Fribourg, Switzerland
6Food Research and Innovation Center, University of Fribourg, Fribourg, Switzerland
7Department of Biomedicine, University of Basel, Basel, Switzerland
Presenting Author: Wolfgang Weber-Fahr

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References

1. Smolensky IV, Zajac-Bakri K, Gass P, Inta D. Ketogenic diet for mood disorders: from animal models to clinical application. J Neural Transm. 2023;130(10):1637-1654. doi:10.1007/s00702-023-02673-5 [doi]
2. Smolensky I. Sex-specific differences in metabolic hormone and adipose tissue dynamics induced by moderate low-carbohydrate and ketogenic diet. Sci Rep. 2023;13:17703. doi:10.1038/s41598-023-44469-1 [doi]
3. Gzieło K, Janeczko K, Węglarz W, Jasiński K, Kłodowski K, Setkowicz Z. MRI spectroscopic and tractography studies indicate consequences of long-term ketogenic diet. Brain Struct Funct. 2020;225(7):2077-2089. doi:10.1007/s00429-020-02111-9 [doi]
4. Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience. 2007;145(1):256-264. doi:10.1016/j.neuroscience.2006.11.065 [doi]
5. Gough SM, Casella A, Ortega KJ, Hackam AS. Neuroprotection by the ketogenic diet: evidence and controversies. Front Nutr. 2021;8:782657. doi:10.3389/fnut.2021.782657 [doi]
6. Hernandez AR, Hernandez CM, Campos KT, Truckenbrod LM, Sakarya Y, McQuail JA, Carter CS, Bizon JL, Maurer AP, Burke SN. The antiepileptic ketogenic diet alters hippocampal transporter levels and reduces adiposity in aged rats. J Gerontol A Biol Sci Med Sci. 2018;73(4):450–458. doi:10.1093/gerona/glx193. PMID: 29040389; PMCID: PMC5861916. [doi] [pmid]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/666-03-014