Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
505-03-008 ISMRM Abstract

In-vivo Axonal Diameter Mapping at 400 mT/m with Next-Generation Gradient Driver Technology on a High-Performance Gradient.

Primary: Neuro - White Matter
Secondary: Diffusion - Microstructure
505-03-008 · Teasing Out the Microstructure of the Brain and Nervous System · Wednesday, 13 May, 1:40 PM–3:30 PM · Ballroom West
Keywords: Gradients Ultra-strong gradients Ultra-high b-value High Performance Gradients Axonal diameter modeling
Accepted
Nastaren Abad1, Eric Fiveland1, John Hotaling1, Anil K Siddavatam1, David Langan1, Rohail Hasan1, SEUNG-KYUN LEE1, Eric Budesheim1, Melissa Freeman2, Jason Stich2, Saban Kurucay2, Thomas K Foo 3
1GE HealthCare Technology and Innovation Center, Niskayuna, United States of America
2GE HealthCare (Waukesha, US), Waukesha, United States of America
3Technology and Innovation Center, GE HealthCare, San Ramon, United States of America
Presenting Author: Thomas K Foo

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Foo, T.K.F., et al., Highly efficient head-only magnetic field insert gradient coil for achieving simultaneous high gradient amplitude and slew rate at 3.0T (MAGNUS) for brain microstructure imaging. Magnetic Resonance in Medicine, 2020. 83(6): p. 2356-2369.
2. Huang, S.Y., et al., Connectome 2.0: Developing the next-generation ultra-high gradient strength human MRI scanner for bridging studies of the micro-, meso- and macro-connectome. Neuroimage, 2021. 243: p. 118530.
3. Feinberg, D.A., et al., Next-generation MRI scanner designed for ultra-high-resolution human brain imaging at 7 Tesla. Nat Methods, 2023. 20(12): p. 2048-2057.
4. Lee, S.K., et al., Peripheral nerve stimulation characteristics of an asymmetric head-only gradient coil compatible with a high-channel-count receiver array. Magn Reson Med, 2016. 76(6): p. 1939-1950.
5. Tan, E.T., et al., Peripheral nerve stimulation limits of a high amplitude and slew rate magnetic field gradient coil for neuroimaging. Magn Reson Med, 2020. 83(1): p. 352-366.
6. Lee, S.K., T.P. Eagan, and D.T.B. Yeo, Derivation and properties of the convolution model for MRI gradient-induced cardiac stimulation. Phys Med Biol, 2025. 70(19).
7. Sabaté, J.A., et al., Magnetic Resonance Imaging Power: High-Performance MVA Gradient Drivers. IEEE Journal of Emerging and Selected Topics in Power Electronics, 2016. 4(1): p. 280-292.
8. Wang, R.R., et al., H-bridge building block with SiC power MOSFETs for pulsed power applications. 2016 IEEE Energy Conversion Congress and Exposition (ECCE), 2016: p. 1-6.
9. Abad, N., et al. Imaging at 400 mT/m with next-generation gradient driver technology on a high-performance gradient platform. in International Society for Magnetic Resonance in Medicine. 2025. Honolulu, HI.
10. Abad, N., et al., Feasibility of brain intra-axonal microstructure imaging with ultrahigh B-encoding using MAGNUS ultra-high-performance gradients. Imaging Neuroscience, 2025. 3.
11. Veraart, J., et al., Nonivasive quantification of axon radii using diffusion MRI. Elife, 2020. 9.
12. Veraart, J., et al., The variability of MR axon radii estimates in the human white matter. Human Brain Mapping, 2021. 42(7): p. 2201-2213.
13. Burcaw, L.M., E. Fieremans, and D.S. Novikov, Mesoscopic structure of neuronal tracts from time-dependent diffusion. Neuroimage, 2015. 114: p. 18-37.
14. Nilsson, M., et al., Resolution limit of cylinder diameter estimation by diffusion MRI: The impact of gradient waveform and orientation dispersion. NMR Biomed, 2017. 30(7).

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/505-03-008