Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
561-03-002 ISMRM Abstract

Proof-of-Principle Implementation of the NOGSE Diffusion Sequence on a Clinical MRI Scanner

Primary: Diffusion - Microstructure
Secondary: Acquisition & Reconstruction - Pulse Sequence Design and Spatial Encoding Methods
561-03-002 · Fancy Sequences and Encoding Strategies · Wednesday, 13 May, 1:40 PM–2:35 PM · Digital Posters Row B
Keywords: Contrast Mechanisms Diffusion Acquisition Microstructure Pulse Sequence Design Diffusion-weighted MRI
Accepted
Milena Capiglioni 1, Stefano Tambalo2,3, Jorge Jovicich2, Analia E Zwick4,5,6, Gonzalo A Alvarez4,5,6
1Support Center for Advanced Neuroimaging (SCAN), Institute for Diagnostic and Interventional Neuroradiology, Bern University Hospital and University of Bern, Bern, Switzerland
2Center for Mind/Brain Sciences (CIMeC), University of Trento, Rovereto, Italy
3Dept. of Physics, Dept of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy
4Centro Atómico Bariloche, CONICET, CNEA, S. C. de Bariloche, Argentina
5Instituto Balseiro, CNEA, Universidad Nacional de Cuyo, S. C. de Bariloche, Argentina, Argentina
6Instituto de Nanociencia y Nanotecnologia, CNEA, CONICET, S. C. de Bariloche, Argentina
Presenting Author: Milena Capiglioni

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Stepišnik J. Time-dependent self-diffusion by NMR spin-echo. Physica B 1993; 183: 343–350. https://doi.org/10.1016/0921-4526(93)90124-O. [doi]
2. Callaghan PT, Stepisnik J. Frequency-domain analysis of spin motion using modulated-gradient NMR. J. Magn. Reson. A 1995; 117:118-122. https://doi.org/10.1006/jmra.1995.9959. [doi]
3. Stepišnik J, Mohorič A., Duh A. Diffusion and flow in a porous structure by the gradient spin echo spectral analysis. Physica B 2001; 307:158–168. https://doi.org/10.1016/S0921-4526(01)01025-0 [doi]
4. Stepisnik J, et al. Spectral characterization of diffusion in porous media by the modulated gradient spin echo with CPMG sequence. Journal of Magnetic Resonance. 2006; 182:195. https://doi.org/10.1016/j.jmr.2006.06.023. [doi]
5. Gore JC, Xu J, Colvin DC, Yankeelov TE, Parsons EC, Does MD. Characterization of tissue structure at varying length scales using temporal diffusion spectroscopy. NMR Biomed. 2010; 23:745. https://doi.org/10.1002/nbm.1531. [doi]
6. White NS, et al. Probing tissue microstructure with restriction spectrum imaging: Histological and theoretical validation. Hum. Brain Mapp. 2013; 34:327. https://doi.org/10.1002/hbm.21454. [doi]
7. Álvarez GA, Shemesh N, Frydman L. Coherent dynamical recoupling of diffusion-driven decoherence in magnetic resonance. Phys. Rev. Lett. 2013; 111:080404. https://doi.org/10.1103/PhysRevLett.111.080404. [doi]
8. Shemesh, N., Álvarez, G. A. & Frydman, L. Measuring small compartment dimensions by probing diffusion dynamics via Non-uniform Oscillating-Gradient Spin-Echo (NOGSE) NMR. Journal of Magnetic Resonance 237, 49–62 (2013). https://doi.org/10.1016/j.jmr.2013.09.009. [doi]
9. Xu J, Li H, Harkins KD, Jiang X, Xie J, Kang H, Does MD, Gore JC. Mapping mean axon diameter and axonal volume fraction by MRI using temporal diffusion spectroscopy. Neuroimage 2014; 103:10. https://doi.org/10.1016/j.neuroimage.2014.09.006. [doi]
10. Shemesh N, Álvarez GA, Frydman L. Size distribution imaging by Non-Uniform Oscillating-Gradient Spin Echo (NOGSE) MRI. PLoS ONE 2015; 10:e0133201. https://doi.org/10.1371/journal.pone.0133201. [doi]
11. Capiglioni, M., Zwick, A., Jiménez, P. & Álvarez, G. A. Noninvasive Quantitative Imaging of Selective Microstructure Sizes via Magnetic Resonance. Phys Rev Appl 15, 014045 (2021). https://doi.org/10.1103/PhysRevApplied.15.014045. [doi]
12. Saidman EL, Zwick A, Tambalo S, Feiweier T, Jovicich J, and Álvarez GA. Selective filters of translational molecular diffusion dynamics in white matter microstructures with preclinical and clinical MRI. Proc. Intl. Soc. Mag. Reson. Med. 2023; 31:0970.
13. Analia Zwick, Ezequiel L. Saidman, Stefano Tambalo, Manuela Moretto, Lisa Novello, Thorsten Feiweier, Jorge Jovicich, and Gonzalo A. Alvarez. Selective filters of translational molecular diffusion dynamics in human brain microstructures. Proc. Intl. Soc. Mag. Reson. Med. 32, 0116 (2024).
14. Ignacio Lembo Ferrari, Manuel Avellaneda, Ezequiel L. Saidman, Francisco Divi, and Gonzalo A. Alvarez. Selective probe of intra- and extra-cellular diffusion with non-invasive MRI using non-uniform oscillating gradients. Proc. Intl. Soc. Mag. Reson. Med. 32 (2024) 3469.
15. Manuel Avellaneda, Ignacio Lembo Ferrari, and Gonzalo A. Alvarez. Diffusion spectrums of intra- and extra-cellular molecular diffusion via Oscillating Gradient Spin-Echo MRI-techniques. Proc. Intl. Soc. Mag. Reson. Med. 32 (2024) 3473.
16. Melisa L. Gimenez, Pablo Jimenez, Leonardo A. Pedraza Pérez, Diana Betancourth, Analia Zwick, and Gonzalo A. Álvarez. Optimisation and impact of gradient waveform modulation on Non-uniform Oscillating Gradient Spin-Echo sequences for microstructural. J. Magn. Reson. 380, 107940 (2025). https://doi.org/10.1016/j.jmr.2025.107940. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/561-03-002