Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
665-03-015 ISMRM Abstract

Investigation of Metabolite Alterations in MELAS patient

Primary: Neuro - Epilepsy
Secondary: Brain Function and fMRI - fMRI Analysis
665-03-015 · fMRI: Applications in Neurology and Psychiatry III · Thursday, 14 May, 1:40 PM–2:35 PM · Digital Posters Row F
Keywords: MRS Glutamate Acute-phase MELAS Glutamine
Accepted
yan zhang 1, Jiaxiang xin2, qichao cheng, xingpeng li3, kunqian ji, anning li
1Department of Radiology, Qilu Hospital of Shandong University, Qilu Medical Imaging Institute of Shandong University, Jian, China
2MR Research Collaboration, Siemens Healthineers Ltd., Shanghai, China
3radiology, department of radiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, beijing, China
Presenting Author: yan zhang

Synopsis

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References

1. [1] Kaufmann P, Engelstad K, Wei Y, Kulikova R, Oskoui M, Battista V, et al. Protean phenotypic features of the A3243G mitochondrial DNA mutation. Arch Neurol. (2009) 66:85-91. doi: 10.1001/archneurol.2008.526. [doi]
2. [2] Tetsuka S, Ogawa T, Hashimoto R, Kato H. Clinical features, pathogenesis, and management of stroke-like episodes due to MELAS.Metab Brain Dis. 2021;36(8):2181-2193. doi:10.1007/s11011-021-00772-x. [doi]
3. [3] Chan F, Lax NZ, Voss CM, et al. The role of astrocytes in seizure generation: insights from a novel in vitro seizure model based on mitochondrial dysfunction. Brain. 2019;142(2):391-411. doi:10.1093/brain/awy320 [doi]
4. [4] Guerrero-Molina MP, Morales-Conejo M, Delmiro A, et al. Elevated glutamate and decreased glutamine levels in the cerebrospinal fluid of patients with MELAS syndrome. J Neurol. 2022;269(6):3238-3248. doi:10.1007/s00415-021-10942-7 [doi]
5. [5] Niu FN, Meng HL, Chang LL, et al. Mitochondrial dysfunction and cerebral metabolic abnormalities in patients with mitochondrial encephalomyopathy subtypes: Evidence from proton MR spectroscopy and muscle biopsy. CNS Neurosci Ther. 2017;23(8):686-697. doi:10.1111/cns.12714 [doi]
6. [6] Wang R, Hu B, Sun C, Geng D, Lin J, Li Y. Metabolic abnormality in acute stroke-like lesion and its relationship with focal cerebral blood flow in patients with MELAS: Evidence from proton MR spectroscopy and arterial spin labeling. Mitochondrion. 2021;59:276-282. doi:10.1016/j.mito.2021.06.012 [doi]

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http://echo.ismrm.org/p/ISMRM2026/665-03-015