567-05-008 ISMRM Abstract

Signal enhancement of gadoquatrane for routine clinical pulse sequences: a phantom study in human plasma

Primary: Contrast Mechanisms - Contrast Agents

Secondary: Preclinical Animal & in vitro MR - Other Preclinical

567-05-008 · Novel Contrast Mechanisms I · Wednesday, 13 May, 4:00 PM–4:55 PM · Digital Posters Row H

Keywords: Phantoms Gadolinium Based Contrast Agents Human plasma Signal Intensity

Accepted

Gregor Jost ¹, Hubertus Pietsch¹

¹Radiology, Bayer AG, Berlin, Germany

Presenting Author: Gregor Jost

Synopsis

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References

1. Lohrke J, Berger M, Frenzel T, et al. Preclinical profile of gadoquatrane: a novel tetrameric, macrocyclic high relaxivity gadolinium-based contrast agent. Invest Radiol. 2022;57(10):629-638. doi: 10.1097/RLI.0000000000000889 [doi]

2. Hofmann BM, Riecke K, Klein S, et al. Pharmacokinetics, safety, and tolerability of the novel tetrameric, high-relaxivity, macrocyclic gadolinium-based contrast agent gadoquatrane in healthy adults. Invest Radiol. 2024;59(2):140-149. doi: 10.1097/RLI.0000000000001043 [doi]

3. Szomolanyi P, Frenzel T, Noebauer-Huhmann IM, et al. Impact of concentration and dilution of three macrocyclic gadolinium-based contrast agents on MRI signal intensity at 1.5T and 3T and different pulse sequences: results of a phantom study in human plasma. Acta Radiol. 2021;62(1):51-57. doi: 10.1177/0284185120915674 [doi]

4. Hadizadeh, D. R., Jost, G., Pietsch, H., Weibrecht, M., Perkuhn, M., Boschewitz, J. M., ... & Willinek, W. A. (2014). Intraindividual quantitative and qualitative comparison of gadopentetate dimeglumine and gadobutrol in time-resolved contrast-enhanced 4-dimensional magnetic resonance angiography in minipigs. Investigative Radiology, 49(7), 457-464. doi: 10.1097/RLI.0000000000000036 [doi]

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http://echo.ismrm.org/p/ISMRM2026/567-05-008