Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
402-02-008 ISMRM Abstract

pH imaging using hyperpolarized [1,5-13C2]Z-OMPD in kidneys of pig models at 3 T

Primary: Contrast Mechanisms - Hyperpolarized MR (Non-Gas)
Secondary: Preclinical Animal & in vitro MR - Probes & Targets
402-02-008 · Inside the Bean: Advances in Renal MRI · Tuesday, 12 May, 8:20 AM–10:10 AM · Hall 1B
Keywords: Probes and Targets Hyperpolarized 13C MRI Large animal model Kidney function PH imaging
Accepted
Martin Grashei 1, Esben S Hansen2, Pascal Wodtke3, Uffe Kjærgaard2, Alixander S Khan2, Kristine H Hinzel2, Tau Vendelboe2, Duy Anh Dang2, Ferdia Gallagher3, Christoffer Laustsen2, Franz Schilling1
1TUM University Hospital, Technical University of Munich (TUM), Munich, Germany
2MR Research Centre, Aarhus University, Aarhus, Denmark
3Department of Radiology, University of Cambridge, Cambridge, United Kingdom
Presenting Author: Martin Grashei

Synopsis

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References

1. Granja S, Tavares-Valente D, Queiros O, et al. Value of pH regulators in the diagnosis, prognosis and treatment of cancer. Seminars in Cancer Biology 2017;43:17-34. doi:10.1016/j.semcancer.2016.12.003 [doi]
2. Burke TJ, Malhotra D, Shapiro JI. Factors maintaining a pH gradient within the kidney: role of the vasculature architecture. Kidney Int. 1999;56(5):1826-1837. doi:10.1046/j.1523-1755.1999.00738.x [doi]
3. Griffiths J. Are cancer cells acidic?. Br J Cancer 1991;64:425–427. doi:10.1038/bjc.1991.326 [doi]
4. Tafech A, Stéphanou A. On the Importance of Acidity in Cancer Cells and Therapy. Biology 2024;13(4):225. doi:10.3390/biology13040225 [doi]
5. Anemone A, Consolino L, Arena F, et al. Imaging tumor acidosis: a survey of the available techniques for mapping in vivo tumor pH. Cancer Metastatis Rev. 2019;38:25-49. doi: 10.1007/s10555-019-09782-9 [doi]
6. Grashei M, Wodtke P, Skinner JG, et al. Simultaneous magnetic resonance imaging of pH, perfusion and renal filtration using hyperpolarized 13C-labelled Z-OMPD. Nat Commun. 2023;14(1):5060. doi:10.1038/s41467-023-40747-3 [doi]
7. Abdulmojeed MB, Grashei M, Dilday S, et al. SABRE-SHEATH Hyperpolarization of [1,5-13C2]Z-OMPD for Noninvasive pH Sensing. ACS Sensors 2024;9(12):6372-6381. doi: 10.1021/acssensors.4c01102 [doi]
8. Ferrari A, Peters J, Anikeeva M, et al. Performance and reproducibility of 13C and 15N hyperpolarization using a cryogen-free DNP polarizer. Sci Rep. 2022;12,11694. doi: 10.1038/s41598-022-15380-7 [doi]
9. Layton AT, Layton HE. A computational model of epithelial solute and water transport along a human nephron. PLoS Comput Biol. 2019;15(2):e1006108. doi:10.1371/journal.pcbi.1006108 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/402-02-008