Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
301-04-008 ISMRM Abstract

Fat-corrected CEST Imaging of the Human Liver at 7T

Primary: Contrast Mechanisms - CEST / APT / NOE
Secondary: Body - Liver
301-04-008 · Innovations in Contrast Mechanisms for MRI · Monday, 11 May, 4:10 PM–6:00 PM · Hall 1A
Keywords: CEST / APT / NOE Fat and Fat/Water Separation Liver FATLESS
Accepted
Petr Menshchikov 1, Petr Bulanov1,2, Neele Kempa1,2, Philip S Boyd1, Mark E Ladd1,2,3, Peter Bachert1,2, Max Lutz4, Sebastian Schmitter1,4,5, Andreas Korzowski1
1Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
2Faculty of Physics and Astronomy, Heidelberg University, Heidelberg, Germany
3Faculty of Medicine, Heidelberg University, Heidelberg, Germany
4Physikalisch Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany
5Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States of America
Presenting Author: Petr Menshchikov

Synopsis

Motivation:
Goals:
Approach:
Results:
Full abstract & presentation

The full text, figures, and any recorded presentation for this abstract are not shown here. Log in if you are a member or registered attendee with access.

Full abstracts, figures, and presentations for Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition are available to registered attendees. This content becomes freely available to the public roughly two years after the meeting.

To request or purchase access, contact the ISMRM Central Office at info@ismrm.org.

Log in

References

1. Zhou, Jinyuan, et al. "Review and consensus recommendations on clinical APT‐weighted imaging approaches at 3T: application to brain tumors." Magnetic resonance in medicine 88.2 (2022): 546-574.doi: 10.1002/mrm.29241 [doi]
2. Kroh F, von Knebel Doeberitz N, Breitling J, et al. Semi-solid MT and APTw CEST-MRI predict clinical outcome of patients with glioma early after radiotherapy. Magn Reson Med 2023;90:1569–1581. doi: 10.1002/mrm.29746 [doi]
3. Knebel Doeberitz NV, Kroh F, Breitling J, et al. CEST Imaging of the APT and ssMT predict the overall survival of patients with glioma at the first follow-up after completion of radiotherapy at 3T. Radiother Oncol 2023:109694. doi: 10.1016/j.radonc.2023.109694 [doi]
4. Vinogradov E, Keupp J, Dimitrov IE, Seiler S, Pedrosa I. CEST-MRI for body oncologic imaging: are we there yet? NMR Biomed 2023;36:e4906. DOI: 10.1002/nbm.4906 [doi]
5. Wu, X., Schmitter, S., Auerbach, E. J., Uğurbil, K. & Moortele, P.-F. V. de. Mitigating transmit B1 inhomogeneity in the liver at 7T using multispoke parallel transmit RF pulse design. Quantitative Imaging in Medicine and Surgery 4, 40–10 (2014). doi: 10.3978/j.issn.2223-4292.2014.02.06 [doi]
6. Bulanov, Petr, et al. "Human liver CEST imaging at 7 T: Impact of B1+ shimming." Magnetic resonance in medicine 94.4 (2025): 1604-1615. DOI: 10.1002/mrm.30557 [doi]
7. Dag, Nurullah, et al. "Diagnostic Performance of Ultrasound‐Based Liver Fat Quantification With Reference to Magnetic Resonance Imaging Proton Density Fat Fraction and Histology." Journal of Clinical Ultrasound (2025). (https://doi.org/10.1002/jcu.24010) [doi]
8. Boyd, Philip S., et al. "Unlocking the rNOE-CEST Contrast for Breast Cancer MRI Using the FATLESS Approach." Investigative Radiology (2024): 10-1097. DOI: 10.1097/RLI.0000000000001222 [doi]
9. Orzada S, Quick HH, Ladd ME, et al. A flexible 8‐channel transmit/receive body coil for 7 T human imaging. In Proceedings of the 17th Annual Meeting of ISMRM, International Society for Magnetic Resonance in Medicine, Honolulu, HI, 17‐24 April 2009; 2009.
10. Lutz, M. et al. B1-MRF: Large dynamic range MRF-based absolute B1+ mapping in the human body at 7T. Magn Reson Med (2024) doi:10.1002/mrm.30242 [doi]
11. Herz K, Mueller S, Perlman O, et al. Pulseq-CEST: Towards multi-site multi-vendor compatibility and reproducibility of CEST experiments using an open-source sequence standard. Magn Reson Med 2021;86:1845–1858. DOI: 10.1002/mrm.28825 [doi]
12. Zimmermann F, Korzowski A, Breitling J, Meissner JE, Schuenke P, Loi L, Zaiss M, Bickelhaupt S, Schott S, Schlemmer HP, Paech D. A novel normalization for amide proton transfer CEST MRI to correct for fat signal–induced artifacts: application to human breast cancer imaging. Magnetic resonance in medicine. 2020; 83(3): 920-34. doi: 10.1002/mrm.27983 [doi]
13. Ren J, Dimitrov I, Sherry AD, Malloy CR. Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. Journal of lipid research. 2008; 49(9): 2055-62. doi: 10.1194/jlr.D800010-JLR200 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/301-04-008