Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
468-01-002 ISMRM Abstract

Assessing Brain Mechanical Anisotropy in Amyotrophic Lateral Sclerosis with MR elastography

Primary: Contrast Mechanisms - Elastography
Secondary: Neuro - Other Neurodegeneration
468-01-002 · Quantitative Neuroimaging of Neurodegeneration, Metabolism, and Brain Microstructure · Tuesday, 12 May, 8:20 AM–9:15 AM · Digital Posters Row I
Keywords: Amyotrophic lateral sclerosis Magnetic Resonance Elastography Mechanical Anisotropy
Accepted
Shengyuan Ma 1,2,3, Peijun Zhao1,2,3, Peng Hu4, Yining Wang5, Fuhua Yan6, Guang-Zhong Yang1,2,3, Torben Breithaupt7, Michael Scheel8, Ingolf Sack9, Yuan Feng1,2,3
1School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China
2Institute of Medical Robotics, Shanghai Jiao Tong University, Shanghai 200240, China
3National Engineering Research Center of Advanced Magnetic Resonance Technologies for Diagnosis and Therapy (NERC-AMRT), Shanghai Jiao Tong University, Shanghai 200240, China
4School of Biomedical Engineering, ShanghaiTech University, Shanghai, China
5Peking Union Medical College Hospital, Beijing, China
6Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China
7University Medicine Lübeck, Germany
8Department of Neuroradiology, Charité – Universitätsmedizin Berlin, Berlin, Germany
9Department of Radiology, Charité – Universitätsmedizin Berlin, Berlin, Germany
Presenting Author: Shengyuan Ma

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References

1. Feng Y, Murphy MC, Hojo E, Li F, Roberts N. Magnetic Resonance Elastography in the Study of Neurodegenerative Diseases. Magnetic Resonance Imaging. April 2023:jmri.28747. doi:10.1002/jmri.28747 [doi]
2. Sack I. Magnetic resonance elastography from fundamental soft-tissue mechanics to diagnostic imaging. Nat Rev Phys. 2022;5(1):25-42. doi:10.1038/s42254-022-00543-2 [doi]
3. Romano A, Guo J, Prokscha T, et al. In Vivo Waveguide Elastography: Effects of Neurodegeneration in Patients with Amyotrophic Lateral Sclerosis. MAGNETIC RESONANCE IN MEDICINE. 2014;72(6):1755-1761. doi:10.1002/mrm.25067 [doi]
4. Ma S, He Z, Wang R, et al. Measurement of biomechanical properties of transversely isotropic biological tissue using traveling wave expansion. Medical Image Analysis. 2025;101:103457. doi:10.1016/j.media.2025.103457 [doi]
5. Filippini N, Douaud G, Mackay CE, Knight S, Talbot K, Turner MR. Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology. 2010;75(18):1645-1652. doi:10.1212/WNL.0b013e3181fb84d1 [doi]
6. Cardenas AM, Sarlls JE, Kwan JY, et al. Pathology of callosal damage in ALS: An ex-vivo, 7T diffusion tensor MRI study. NeuroImage: Clinical. 2017;15:200-208. doi:10.1016/j.nicl.2017.04.024 [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/468-01-002