Cape Town - 2026 ISMRM-ISMRT Annual Meeting and Exhibition
9 May 2026 – 14 May 2026 · Cape Town, South Africa
669-04-007 ISMRM Abstract

Small-bowel motility is lower in humans with obesity vs. healthy weight and this is altered by weight loss – an MRI study

Primary: Body - Digestive
Secondary: Acquisition & Reconstruction - Quantitative Imaging: chest, abdomen, and pelvis
669-04-007 · Twists and Turns: Pancreas, Cholangio, and Bowel MRI · Thursday, 14 May, 2:35 PM–3:30 PM · Digital Posters Row J
Keywords: Obesity Gastrointestinal motility Gastrointestinal function Normal weight Cine-MRI
Accepted
Catharina S de Jonge 1,2, Katy A van Galen2,3, Femke Struik1, Susanne E la Fleur2,3,4, Mireille J Serlie2,3,5
1Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
2Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, Netherlands
3Department of Endocrinology and Metabolism, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
4Department of Clinical Chemistry, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands
5Department of Endocrinology, Yale School of Medicine, New Haven, United States of America
Presenting Author: Catharina S de Jonge

Synopsis

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References

1. Miron, I. et al. GASTROINTESTINAL MOTILITY DISORDERS IN OBESITY. Acta Endocrinol (Buchar). 2019 Oct-Dec;15(4):497-504. doi: 10.4183/aeb.2019.497. [doi]
2. Simpson, E.J. et al. The effect of oral feeding on gastrointestinal function, motility and appetite-regulating hormones, insulin, glucose and satiety in normal weight individuals and those with obesity. Clin Nutr. 2025 Sep;52:62-71. doi: 10.1016/j.clnu.2025.07.008. [doi]
3. Odille, F. et al. Quantitative assessment of small bowel motility by nonrigid registration of dynamic MR images. Magn Reson Med. 2012 Sep;68(3):783-93. doi: 10.1002/mrm.23298. [doi]
4. van Galen, K.A. et al. Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study. Nat Metab. 2023 Jun;5(6):1059-1072. doi: 10.1038/s42255-023-00816-9. [doi]
5. de Jonge, C.S. et al. Detecting the effects of a standardized meal challenge on small bowel motility with MRI in prepared and unprepared bowel. Neurogastroenterol Motil. 2019 Feb;31(2):e13506. doi: 10.1111/nmo.13506. [doi]
6. Deloose, E. et al. The migrating motor complex: control mechanisms and its role in health and disease. Nat Rev Gastroenterol Hepatol. 2012 Mar 27;9(5):271-85. doi: 10.1038/nrgastro.2012.57. [doi]

Cite this abstract

http://echo.ismrm.org/p/ISMRM2026/669-04-007